What is the NOAEL for Malachite green?
Malachite green has 12 NOAEL studies in the database. The lowest reported value is 5.9 mg/kg bw/day via oral in Rat. Source: ToxValDB_EFSA.
NOAEL Data
Cosmetic Ingredient
Malachite green
Also known as: Malachite green chloride, Bronze Green Toner A-8002, Caswell No. 534C, China Green, Diamond Green P Extra (+15 more)
CAS 569-64-2
Malachite green (CAS 569-64-2) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, EPA TRI.
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Malachite green
CAS Number
569-64-2
DTXSID
DTXSID1025512
Molecular Formula
C23H25N2.ClH
InChI Key
FDZZZRQASAIRJF-UHFFFAOYSA-M
Monoisotopic Mass
365.178452
Synonyms
Malachite green chlorideBronze Green Toner A-8002Caswell No. 534CChina GreenDiamond Green P Extra(4-(4-Dimethylaminobenzhydriylidene)cyclohexa-2,5-dienylidene)dimethylammonium chlorideEINECS 209-322-8EPA Pesticide Chemical Code 039504Fast Green OMalachite Green J3ENew Victoria Green Extra INew Victoria Green Extra O
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =5.9 | mg/kg bw/day | BMDL (05) | oral | Rat | ToxValDB_EFSA |
| =13 | mg/kg bw/day | BMDL (10) | oral | Mouse | ToxValDB_EFSA |
| =20 | mg/kg bw/day | BMDL (10) | oral | Mouse | ToxValDB_WHO_JECFA_Tox_Studies |
| 12058M7ORO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 12058M7ORO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 12058M7ORO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 12058M7ORO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| =12 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
| 600 | ppm | POLY-3 lowest dose | Dosed feed | Rat | NTP_ICE_cancer |
| 450 | ppm | Top dose | Dosed feed | Mouse | NTP_ICE_cancer |
| 600 | ppm | Top dose | Dosed feed | Rat | NTP_ICE_cancer |
Showing 12 of 12 studies
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| C.I. Basic Green 4 (Malachite green) | - | - |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BRILLIANT GREEN HYDROCHLORIDE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Malachite green?
Malachite green appears on 3 regulatory/inventory lists including Europe; Personal care - hair coloring, Canada; pharmaceutical, active_ingredient; Europe; Pesticides. Source: EPA CPDat.
Is Malachite green used in cosmetics?
Yes, Malachite green is also indexed as a cosmetic ingredient under the name Basic Green 4. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Malachite green come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Malachite green used outside industrial chemicals?
Malachite green also appears in cosmetics, pharmaceutical, cannabis databases.