What is the NOAEL for Hexadecyltrimethylammonium bromide?
Hexadecyltrimethylammonium bromide has 21 NOAEL studies in the database. The lowest reported value is -0.1 % via Dermal. Source: NTP ICE skin sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Hexadecyltrimethylammonium bromide
Also known as: Cetyl trimethyl ammonium bromide, Cetrimide, Bromat, Caswell No. 167, Cetaflon (+15 more)
CAS 57-09-0
Hexadecyltrimethylammonium bromide (CAS 57-09-0) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
Hexadecyltrimethylammonium bromide is classified GHS Danger (H302, H315, H318, H335, H373, H400, H410, H312) in the chemicals database but is restricted in EU cosmetics at max 0.1% as preservative (Annex V Entry 44); rinse-off up to 2.5%; leave-on hair up to 1.0%; leave-on face up to 0.5%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
21
SOURCE
Chemical inventory jurisdictions
Regulatory lists
6
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
25 fields
Name
Hexadecyltrimethylammonium bromide
CAS Number
57-09-0
Molecular Formula
C19H42N.BrH
InChI Key
LZZYPRNAOMGNLH-UHFFFAOYSA-M
Monoisotopic Mass
364.257888
Synonyms
Cetyl trimethyl ammonium bromideCetrimideBromatCaswell No. 167CetaflonCetarolCetavlon bromideCetrimide bpCirrasol-ODCycloton VEINECS 200-311-3EPA Pesticide Chemical Code 069117
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
13 records
Surfactant (surface active agent)BiocidePreservativeAnti-static agentEmulsifier
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 21 of 21 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 7.396 | uM | AC50 | - | - | NTP ICE endocrine |
| 46.28 | uM | AC50 | - | - | NTP ICE endocrine |
| 6.791 | uM | ACC | - | - | NTP ICE endocrine |
| 28.54 | uM | ACC | - | - | NTP ICE endocrine |
| =0.0987 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 2.4 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| -0.1 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 96 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP ICE eye irritation |
| >0.69 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| L64N7M9BWR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | unitless | GHS Classification | Ocular | Rabbit | NTP ICE eye irritation |
| 1.028 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| 0.9488 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 0.35 | %/sec | Intensity | Ocular | - | NTP ICE eye irritation |
| =410 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| 0 | s | Lag time | Ocular | - | NTP ICE eye irritation |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.0837 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.231 | unitless | Model Score | - | - | NTP ICE endocrine |
| =10 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 63 | % | Plateau level | Ocular | - | NTP ICE eye irritation |
Showing 21 of 21 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Cetrimonium bromide | 200-311-3 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.1% as preservative (Annex V Entry 44); rinse-off up to 2.5%; leave-on hair up to 1.0%; leave-on face up to 0.5%
Category
preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CETRIMONIUM BROMIDE
ChEMBL Phase
2
Adverse Events
1499
Bioactivity
2
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Hexadecyltrimethylammonium bromide?
Hexadecyltrimethylammonium bromide appears on 4 regulatory/inventory lists including active_ingredient; Europe; Pesticides, active_ingredient; Australia, pharmaceutical, and 1 more. Source: EPA CPDat.
Is Hexadecyltrimethylammonium bromide used in cosmetics?
Yes, Hexadecyltrimethylammonium bromide is also indexed as a cosmetic ingredient under the name Cetrimonium Bromide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Hexadecyltrimethylammonium bromide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Hexadecyltrimethylammonium bromide have different safety status in cosmetics vs industrial chemicals?
Hexadecyltrimethylammonium bromide is classified GHS Danger (H302, H315, H318, H335, H373, H400, H410, H312) in the chemicals database but is restricted in EU cosmetics at max 0.1% as preservative (Annex V Entry 44); rinse-off up to 2.5%; leave-on hair up to 1.0%; leave-on face up to 0.5%.
Is Hexadecyltrimethylammonium bromide used outside industrial chemicals?
Hexadecyltrimethylammonium bromide also appears in cosmetics, pharmaceutical, cannabis databases.