What is the NOAEL for Cholesterol?
Cholesterol has 5 NOAEL studies in the database. The lowest reported value is 132 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Cholesterol
Also known as: 5:6-Cholesten-3beta-ol, delta5-Cholesten-3beta-ol, SyntheChol, EC No.: 200-353-2, 200-353-2 (+15 more)
CAS 57-88-5
Cholesterol (CAS 57-88-5) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 22 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, IARC, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
5
SOURCE
Chemical inventory jurisdictions
Regulatory lists
22
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Cholesterol
CAS Number
57-88-5
Molecular Formula
C27H46O
InChI Key
HVYWMOMLDIMFJA-DPAQBDIFSA-N
Monoisotopic Mass
386.354866
Synonyms
5:6-Cholesten-3beta-oldelta5-Cholesten-3beta-olSyntheCholEC No.: 200-353-2200-353-2Cholest-5-en-3-beta-olEINECS 200-353-23-beta-Hydroxycholest-5-enedelta(sup 5)-Cholesten-3-beta-olWool alcohols B. P.UNII-97C5T2UQ7JCholesterinum
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 31, Sup 7 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
49 records
Softener and conditionerEmulsifierViscosity modifierStabilizing agentThickening agentFragranceProcessing aids not otherwise specifiedPharmaceutical
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
22 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| detected; wastewater | USGS | United States Geological Survey (USGS) |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; wastewater | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =132 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 97C5T2UQ7J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP ICE cancer |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Cholesterol | 200-353-2 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHOLESTEROL
ChEMBL Phase
2
Adverse Events
84
Bioactivity
5
Frequently Asked Questions
What regulatory lists include Cholesterol?
Cholesterol appears on 11 regulatory/inventory lists including inert_ingredient; Pesticides, Canada; consumer_product; Substances in Products - Canada (4/2014), IFRA Transparency, and 8 more. Source: EPA CPDat.
Is Cholesterol a carcinogen according to IARC?
Cholesterol is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Cholesterol used in cosmetics?
Yes, Cholesterol is also indexed as a cosmetic ingredient under the name Cholesterol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Cholesterol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Cholesterol used outside industrial chemicals?
Cholesterol also appears in cosmetics, pharmaceutical databases.