What is the NOAEL for Idebenone?
Idebenone has 5 NOAEL studies in the database. The lowest reported value is HB6PN45W4J UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Idebenone
Also known as: 6-(10-Hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone, Idebenona, Idebenonum, UNII-HB6PN45W4J, 2,3-dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone (+5 more)
CAS 58186-27-9
Idebenone (CAS 58186-27-9) is a chemical substance. Key regulatory status: 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Idebenone
CAS Number
58186-27-9
DTXSID
DTXSID0040678
Molecular Formula
C19H30O5
InChI Key
JGPMMRGNQUBGND-UHFFFAOYSA-N
Monoisotopic Mass
338.209324
Synonyms
6-(10-Hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinoneIdebenonaIdebenonumUNII-HB6PN45W4J2,3-dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-p-benzoquinone2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-p-benzoquinoneBRN 2001459CV 2619
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Antioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Europe; pharmaceutical | European Medicines Agency | PROTECT ADR database |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| HB6PN45W4J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| HB6PN45W4J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| HB6PN45W4J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| HB6PN45W4J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =10000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 5 of 5 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
sunscreen
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
IDEBENONE
ChEMBL Phase
4
Adverse Events
111
Bioactivity
12
Frequently Asked Questions
What regulatory lists include Idebenone?
Idebenone appears on 3 regulatory/inventory lists including pharmaceutical, Europe; pharmaceutical, Canada; pharmaceutical. Source: EPA CPDat.
Is Idebenone used in cosmetics?
Yes, Idebenone is also indexed as a cosmetic ingredient under the name HYDROXYDECYL UBIQUINONE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Idebenone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Idebenone used outside industrial chemicals?
Idebenone also appears in cosmetics, pharmaceutical databases.