NOAEL Data REACH Registered Cosmetic Ingredient

2,7-Naphthalenediol

Also known as: 4-06-00-06570, BRN 2042383, EINECS 209-478-7, Naphthalenediol-2,7, UNII-0TO8E448UD

CAS 582-17-2

2,7-Naphthalenediol (CAS 582-17-2) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for 2,7-Naphthalenediol →

Cross-Vertical Regulatory Divergence

2,7-Naphthalenediol is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302, H315, H317, H318, H319, H335, H411).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 10 fields

Name

2,7-Naphthalenediol

CAS Number

582-17-2

Molecular Formula

C10H8O2

InChI Key

DFQICHCWIIJABH-UHFFFAOYSA-N

Monoisotopic Mass

160.052429

Synonyms

4-06-00-06570BRN 2042383EINECS 209-478-7Naphthalenediol-2,7UNII-0TO8E448UD

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records

List	Keyword	Source
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care; restricted	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 26 of 26 studies

Value	Unit	Endpoint	Route	Species	Source
60	mg/kg/day	-	oral	rat	Regulatory source
60	mg/kg	-	oral	rat	Regulatory source
60	mg/kg bw/day	-	oral	rat	Regulatory source
60	mg/kg bw	-	oral	rat	Regulatory source
65	mg/kg bw/day	-	-	human	Regulatory source
70	mg/kg bw/day	-	-	rat	Regulatory source
585	mg/kg bw/day	-	-	human	Regulatory source
0TO8E448UD	UNII	FDA UNII substance identifier	-	-	openFDA substances
195	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
=0.04	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=0.06	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=60	mg/kg/day	NOAEL	oral	rat	SCCS Opinion
65	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=65	mg/kg bw/day	NOAEL	-	human	SCCS Opinion
=65	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=70	mg/kg bw/day	NOAEL	-	rat	SCCS Opinion
=585	mg/kg bw/day	NOAEL	-	human	SCCS Opinion
=0.04	mg/kg bw/d	dermal absorption	oral	rat	Regulatory source
=0.06	mg/kg bw/d	dermal absorption	oral	rat	Regulatory source
65	mg/kg bw/day	dermal absorption	dermal	rat	Regulatory source
=65	mg/kg bw/d	dermal absorption	oral	rat	Regulatory source
70	mg/kg bw/day	dermal absorption	dermal	rat	Regulatory source
65	mg/kg bw/day	irritation	-	rat	Regulatory source
70	mg/kg bw/day	irritation	oral	rat	Regulatory source
70	mg/kg bw/day	irritation	dermal	rat	Regulatory source
70	mg/kg bw/day	irritation	-	rat	Regulatory source

Showing 26 of 26 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Naphthalene-2,7-diol	209-478-7	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 3 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/1059/07	21 March 2007	safe	1.0%	sensitisation not excluded
SCCP/1061/06	2007-03-21	The SCCP is of the opinion that the information submitted is insufficient to allow a final risk assessment to be carried out. Before any further consideration, an in vitro percutaneous absorption study should be performed following the relevant SCCNFP/SCCP opinions and in accordance with its Notes of Guidance.	-	Insufficient data (missing in vitro percutaneous absorption study). Moderate skin sensitiser. Clastogenic activity in vitro (V79 cells), but no mutagenic potential in vivo. Extremely irritant/corrosive to rabbit eyes as neat powder.
SCCS/1366/10	21 September 2010	The SCCP is of the opinion that 2,7-Naphthalenediol as an ingredient in oxidative and non-oxidative hair dye formulations at a maximum on-head concentration of 1% does not pose a risk to the health of the consumer, apart from its sensitising potential.	1%	Sensitising potential. No mutagenic potential in vivo; genotoxicity/mutagenicity studies in finished formulations should be undertaken per SCCNFP/SCCP opinions and Notes of Guidance.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

1.0%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL205165

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 2,7-Naphthalenediol?

2,7-Naphthalenediol has 26 NOAEL studies in the database. The lowest reported value is 0.04 mg/kg bw/d via oral in rat. Source: SCCS Opinion.

What regulatory lists include 2,7-Naphthalenediol?

2,7-Naphthalenediol appears on 2 regulatory/inventory lists including Europe; Personal care - hair coloring, Europe; Personal care; restricted. Source: EPA CPDat.

Is 2,7-Naphthalenediol used in cosmetics?

Yes, 2,7-Naphthalenediol is also indexed as a cosmetic ingredient under the name 2,7-Naphthalenediol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2,7-Naphthalenediol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 2,7-Naphthalenediol have different safety status in cosmetics vs industrial chemicals?

2,7-Naphthalenediol is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302, H315, H317, H318, H319, H335, H411).

Is 2,7-Naphthalenediol used outside industrial chemicals?

2,7-Naphthalenediol also appears in cosmetics, pharmaceutical databases.