What is the NOAEL for 2,7-Naphthalenediol?
2,7-Naphthalenediol has 62 NOAEL studies in the database. The lowest reported value is 0.04 mg/kg bw/d via oral in rat. Source: SCCS_vision_codex.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,7-Naphthalenediol
Also known as: 4-06-00-06570, BRN 2042383, EINECS 209-478-7, Naphthalenediol-2,7, UNII-0TO8E448UD
CAS 582-17-2
2,7-Naphthalenediol (CAS 582-17-2) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
Cross-Vertical Regulatory Divergence
2,7-Naphthalenediol is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302, H315, H317, H318, H319, H335, H411).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
62
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
2,7-Naphthalenediol
CAS Number
582-17-2
DTXSID
DTXSID2060387
Molecular Formula
C10H8O2
InChI Key
DFQICHCWIIJABH-UHFFFAOYSA-N
Monoisotopic Mass
160.052429
Synonyms
4-06-00-06570BRN 2042383EINECS 209-478-7Naphthalenediol-2,7UNII-0TO8E448UD
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 62 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 60 | mg/kg/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 60 | mg/kg | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 60 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 60 | mg/kg bw | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 65 | mg/kg bw/day | - | - | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 65 | mg/kg bw/day | - | - | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 65 | mg/kg bw/day | - | - | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 65 | mg/kg bw/day | - | - | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 70 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 70 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 70 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 70 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 585 | mg/kg bw/day | - | - | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 585 | mg/kg bw/day | - | - | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 0TO8E448UD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0TO8E448UD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0TO8E448UD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0TO8E448UD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 195 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| =0.04 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =0.04 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =0.04 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =0.04 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =0.06 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =0.06 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =0.06 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =0.06 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =60 | mg/kg/day | NOAEL | oral | rat | SCCS_vision_codex |
| =60 | mg/kg/day | NOAEL | oral | rat | SCCS_vision_codex |
| =60 | mg/kg/day | NOAEL | oral | rat | SCCS_vision_codex |
| =60 | mg/kg/day | NOAEL | oral | rat | SCCS_vision_codex |
| 65 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =65 | mg/kg bw/day | NOAEL | - | human | SCCS_vision_codex |
| =65 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =65 | mg/kg bw/day | NOAEL | - | human | SCCS_vision_codex |
| =65 | mg/kg bw/day | NOAEL | - | human | SCCS_vision_codex |
| =65 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =65 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =65 | mg/kg bw/day | NOAEL | - | human | SCCS_vision_codex |
| =65 | mg/kg bw/d | NOAEL | oral | rat | SCCS_vision_codex |
| =70 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =70 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =70 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =70 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =585 | mg/kg bw/day | NOAEL | - | human | SCCS_vision_codex |
| =585 | mg/kg bw/day | NOAEL | - | human | SCCS_vision_codex |
| =585 | mg/kg bw/day | NOAEL | - | human | SCCS_vision_codex |
| =585 | mg/kg bw/day | NOAEL | - | human | SCCS_vision_codex |
| =0.04 | mg/kg bw/d | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =0.06 | mg/kg bw/d | dermal absorption | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
Showing 50 of 62 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Naphthalene-2,7-diol | 209-478-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
2 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1411/10 | 21 September 2010 | safe | 1.0% | sensitisation potential not excluded |
| SCCP/1059/07 | 21 March 2007 | safe | 1.0% | sensitisation not excluded |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
1.0%
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL205165
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include 2,7-Naphthalenediol?
2,7-Naphthalenediol appears on 2 regulatory/inventory lists including Europe; Personal care - hair coloring, Europe; Personal care; restricted. Source: EPA CPDat.
Is 2,7-Naphthalenediol used in cosmetics?
Yes, 2,7-Naphthalenediol is also indexed as a cosmetic ingredient under the name 2,7-Naphthalenediol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,7-Naphthalenediol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2,7-Naphthalenediol have different safety status in cosmetics vs industrial chemicals?
2,7-Naphthalenediol is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302, H315, H317, H318, H319, H335, H411).
Is 2,7-Naphthalenediol used outside industrial chemicals?
2,7-Naphthalenediol also appears in cosmetics, pharmaceutical databases.