What is the NOAEL for C.I. Pigment Red 57?
C.I. Pigment Red 57 has 17 NOAEL studies in the database. The lowest reported value is 0 mg/kg bw/day via oral in dog. Source: Regulatory source.
NOAEL Data
REACH Registered
Cosmetic Ingredient
C.I. Pigment Red 57
Also known as: Disodium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]naphthalene-2-carboxylate, C.I. Pigment Red 57, disodium salt, C.I. 15850, D&c red no.6, EINECS 227-497-9 (+7 more)
CAS 5858-81-1
C.I. Pigment Red 57 (CAS 5858-81-1) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
17
SOURCE
Chemical inventory jurisdictions
Regulatory lists
5
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
C.I. Pigment Red 57
CAS Number
5858-81-1
Molecular Formula
C18H14N2O6S.2Na
InChI Key
VPWFPZBFBFHIIL-UHFFFAOYSA-L
Monoisotopic Mass
432.036796
Synonyms
Disodium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]naphthalene-2-carboxylateC.I. Pigment Red 57, disodium saltC.I. 15850D&c red no.6EINECS 227-497-9Japan Red 201Cerven pigment 57UNII-481744AI4OFD&C Red No. 6disodium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoateEC No.: 227-497-9227-497-9
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
23 records
PigmentDye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Arts and crafts/Office supplies - body paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| Europe; Personal care; restricted | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0 | mg/kg bw/day | - | oral | dog | Regulatory source |
| 0.003 | mg/kg bw/d | - | - | rat | Regulatory source |
| 100 | mg/kg bw/day | - | - | dog | Regulatory source |
| 100 | mg/kg bw/day | - | oral | dog | Regulatory source |
| 150 | mg/kg bw/day | - | oral | rat | Regulatory source |
| 150 | mg/kg bw/day | - | - | rat | Regulatory source |
| 481744AI4O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >1.080e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =0 | mg/kg bw/day | NOAEL | oral | dog | SCCS Opinion |
| =0.003 | mg/kg bw/d | NOAEL | - | rat | SCCS Opinion |
| =100 | mg/kg bw/day | NOAEL | - | dog | SCCS Opinion |
| =100 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =150 | mg/kg bw/day | NOAEL | - | rat | SCCS Opinion |
| =150 | mg/kg bw/day | NOAEL | oral | rat | SCCNFP Opinion |
| =150 | mg/kg | NOAEL | oral | rat | SCCNFP Opinion |
| 100 | mg/kg bw/d | genotoxicity | oral | rat | Regulatory source |
| 150 | mg/kg | reproductive toxicity | oral | rat | Regulatory source |
Showing 17 of 17 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Disodium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate | 227-497-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
3 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1475/12 | 18 September 2012 | safe | 0.4% | none noted |
| SCCS/1411/10 | 21 September 2010 | safe | 1.0% | sensitisation potential not excluded |
| SCCS/1411/11 | 2012-10-12 | Therefore, the SCCS concludes that Pigment Red 57 does not pose a risk to the health of the consumer, when used as a direct dye in non-oxidative hair dye formulations, at a maximum on-head concentration of 0.4%. | 0.4% | Toxicological data mostly not complying with current standards; no NOAEL derivable; safety for other cosmetic uses as a colorant (additional exposure) not assessed and recommended to be assessed. |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
0.4%
Category
Other
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include C.I. Pigment Red 57?
C.I. Pigment Red 57 appears on 4 regulatory/inventory lists including Arts and crafts/Office supplies - body paint; detected; Europe, pharmaceutical, Personal care, and 1 more. Source: EPA CPDat.
Is C.I. Pigment Red 57 used in cosmetics?
Yes, C.I. Pigment Red 57 is also indexed as a cosmetic ingredient under the name D&C Red No. 6 (CI 15850). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for C.I. Pigment Red 57 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is C.I. Pigment Red 57 used outside industrial chemicals?
C.I. Pigment Red 57 also appears in cosmetics, food safety databases.