NOAEL Data Cosmetic Ingredient

Formic acid, butyl ester

Also known as: 4-02-00-00028, BRN 1742108, n-Butyl formate, Butyl methanoate, n-Butyl methanoate (+10 more)

CAS 592-84-7

Formic acid, butyl ester (CAS 592-84-7) is a chemical substance. Key regulatory status: 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ILO ICSC.

View cosmetic safety profile for Butyl Formate →

Cross-Vertical Regulatory Divergence

Formic acid, butyl ester is classified GHS Danger (H225, H319, H335) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 21 fields

Name

Formic acid, butyl ester

CAS Number

592-84-7

DTXSID

DTXSID2060468

Molecular Formula

C5H10O2

InChI Key

NMJJFJNHVMGPGM-UHFFFAOYSA-N

Monoisotopic Mass

102.06808

Synonyms

4-02-00-00028BRN 1742108n-Butyl formateButyl methanoaten-Butyl methanoateEINECS 209-772-5FEMA No. 2196NSC 6969Butylester kyseliny mravenciUNII-0Y9MZ7VM9PFEMA 2916Formic acid butyl ester

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Highly flammable liquid and vapour May be harmful if swallowed Causes eye irritation May cause respiratory irritation
Short-term Effects	The vapour is irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 5 records

FragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 9 records

List	Keyword	Source
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 5 of 5 studies

Value	Unit	Endpoint	Route	Species	Source
0Y9MZ7VM9P	UNII	FDA UNII substance identifier	-	-	openFDA substances
0Y9MZ7VM9P	UNII	FDA UNII substance identifier	-	-	openFDA substances
0Y9MZ7VM9P	UNII	FDA UNII substance identifier	-	-	openFDA substances
0Y9MZ7VM9P	UNII	FDA UNII substance identifier	-	-	openFDA substances
=71013.1	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria

Showing 5 of 5 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL BUTYL FORMATE

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Frequently Asked Questions

What is the NOAEL for Formic acid, butyl ester?

Formic acid, butyl ester has 5 NOAEL studies in the database. The lowest reported value is 0Y9MZ7VM9P UNII. Source: openFDA substances.

What regulatory lists include Formic acid, butyl ester?

Formic acid, butyl ester appears on 5 regulatory/inventory lists including air; Cons electronics mech appliances and machinery; detected; emissions; Europe, IFRA Transparency, Europe, and 2 more. Source: EPA CPDat.

Is Formic acid, butyl ester used in cosmetics?

Yes, Formic acid, butyl ester is also indexed as a cosmetic ingredient under the name Butyl Formate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Formic acid, butyl ester come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Does Formic acid, butyl ester have different safety status in cosmetics vs industrial chemicals?

Formic acid, butyl ester is classified GHS Danger (H225, H319, H335) in the chemicals database but is allowed in EU cosmetics.

Is Formic acid, butyl ester used outside industrial chemicals?

Formic acid, butyl ester also appears in cosmetics, pharmaceutical, food safety databases.