What is the NOAEL for P-Tolyl octanoate?
P-Tolyl octanoate has 8 NOAEL studies in the database. The lowest reported value is 065NCY25ZE UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
P-Tolyl octanoate
Also known as: Octanoic acid, 4-methylphenyl ester, Cresyl octanoate, p-, BRN 3270557, p-Cresyl caprylate, EINECS 261-803-1 (+6 more)
CAS 59558-23-5
P-Tolyl octanoate (CAS 59558-23-5) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
P-Tolyl octanoate
CAS Number
59558-23-5
DTXSID
DTXSID9052262
Molecular Formula
C15H22O2
InChI Key
ALRYNTSLFYRKGF-UHFFFAOYSA-N
Monoisotopic Mass
234.16198
Synonyms
Octanoic acid, 4-methylphenyl esterCresyl octanoate, p-BRN 3270557p-Cresyl caprylateEINECS 261-803-1FEMA No. 3733Methylphenyl octanoate, p-Narcissin KTolyl octanoate, P-UNII-065NCY25ZE4-Methylphenyl octanoate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 065NCY25ZE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 065NCY25ZE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 065NCY25ZE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 065NCY25ZE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =1600 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 8 of 8 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include P-Tolyl octanoate?
P-Tolyl octanoate appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is P-Tolyl octanoate used in cosmetics?
Yes, P-Tolyl octanoate is also indexed as a cosmetic ingredient under the name P-CRESYL OCTANOATE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for P-Tolyl octanoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is P-Tolyl octanoate used outside industrial chemicals?
P-Tolyl octanoate also appears in cosmetics, food safety, cannabis databases.