NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

HC Yellow 4

Also known as: HC Yellow No. 4, Ethanol, 2-[[2-(2-hydroxyethoxy)-4-nitrophenyl]amino]-, 2-[[2-(2-Hydroxyethoxy)-4-nitrophenyl]amino]ethanol, 2-[3-Nitro-6-(β-hydroxyethylamino)phenoxy]ethanol, Colorex HCY 4 (+6 more)

CAS 59820-43-8

HC Yellow 4 (CAS 59820-43-8) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, IARC, ECHA REACH.

View cosmetic safety profile for HC Yellow No. 4 →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields

Name

HC Yellow 4

CAS Number

59820-43-8

DTXSID

DTXSID6021458

Molecular Formula

C10H14N2O5

InChI Key

PNENOUKIPPERMY-UHFFFAOYSA-N

Monoisotopic Mass

242.090272

Synonyms

HC Yellow No. 4Ethanol, 2-[[2-(2-hydroxyethoxy)-4-nitrophenyl]amino]-2-[[2-(2-Hydroxyethoxy)-4-nitrophenyl]amino]ethanol2-[3-Nitro-6-(β-hydroxyethylamino)phenoxy]ethanolColorex HCY 4PHENOL, N,O-DI(HYDROXYETHYL)-2-AMINO-5-NITRO-N, O-Di(hydroxyethyl)-2-amino-5-nitrophenol2-[[2-(2-hydroxyethoxy)-4-nitrophenyl]amino]-ethanolEC No.: 428-840-72-(3-Nitro-6-(beta-hydroxyethylamino)phenoxy)ethanolUNII-0N97D5G157

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 3	Not classifiable	1992	57

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 98 studies

Value	Unit	Endpoint	Route	Species	Source
0.1	%	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
43	-	-	dermal	rabbit	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
43	-	-	dermal	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
50	mg/kg bw/d	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
50	mg/kg bw/d	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
50	mg/kg bw/d	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
50	mg/kg bw/d	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
200	mg/kg bw/d	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
300	mg/kg bw/d	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
5000	ppm	-	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
5000	ppm	-	dermal	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
5000	ppm	-	dermal	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
5000	ppm	-	dermal	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
5000	ppm	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
0N97D5G157	UNII	FDA UNII substance identifier	-	-	openFDA substances
0N97D5G157	UNII	FDA UNII substance identifier	-	-	openFDA substances
0N97D5G157	UNII	FDA UNII substance identifier	-	-	openFDA substances
0N97D5G157	UNII	FDA UNII substance identifier	-	-	openFDA substances
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	unitless	IARC group	-	-	NTP_ICE_cancer
=0.001	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=0.001	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=0.001	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=0.001	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=0.1	%	NOAEL	oral	rat	SCCS_vision_codex
=0.1	%	NOAEL	oral	rat	SCCS_vision_codex
=0.1	%	NOAEL	oral	rat	SCCS_vision_codex
=0.1	%	NOAEL	oral	rat	SCCS_vision_codex
=0.4	%	NOAEL	-	rat	SCCS_vision_codex
=0.4	%	NOAEL	-	rat	SCCS_vision_codex
=0.4	%	NOAEL	-	rat	SCCS_vision_codex
=0.4	%	NOAEL	-	rat	SCCS_vision_codex
=1.5	%	NOAEL	oral	rat	SCCS_vision_codex
=1.5	%	NOAEL	oral	rat	SCCS_vision_codex
=1.5	%	NOAEL	oral	rat	SCCS_vision_codex
=1.5	%	NOAEL	oral	rat	SCCS_vision_codex
=43	-	NOAEL	dermal	rabbit	SCCS_vision_codex
=43	-	NOAEL	dermal	rabbit	SCCS_vision_codex
=43	-	NOAEL	dermal	rabbit	SCCS_vision_codex
=43	-	NOAEL	dermal	rabbit	SCCS_vision_codex
=50	mg/kg/d	NOAEL	oral	rat	SCCS_vision_codex
=50	mg/kg bw/d	NOAEL	dermal	rat	SCCS_vision_codex
=50	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=50	mg/kg/d	NOAEL	oral	rat	SCCS_vision_codex
=50	mg/kg bw/d	NOAEL	dermal	rat	SCCS_vision_codex
=50	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=50	mg/kg/d	NOAEL	oral	rat	SCCS_vision_codex
=50	mg/kg bw/d	NOAEL	dermal	rat	SCCS_vision_codex
=50	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=50	mg/kg/d	NOAEL	oral	rat	SCCS_vision_codex

Showing 50 of 98 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2-[[2-(2-hydroxyethoxy)-4-nitrophenyl]amino]ethanol	428-840-7	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1385/10	8 December 2009	safe	1.0%	secondary amine; nitrosamine <50ppb; sensitisation not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

1.5%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1573069

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for HC Yellow 4?

HC Yellow 4 has 98 NOAEL studies in the database. The lowest reported value is 0.001 mg/kg bw via oral in rat. Source: SCCS_vision_codex.

What regulatory lists include HC Yellow 4?

HC Yellow 4 appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.

Is HC Yellow 4 a carcinogen according to IARC?

HC Yellow 4 is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1992). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is HC Yellow 4 used in cosmetics?

Yes, HC Yellow 4 is also indexed as a cosmetic ingredient under the name HC Yellow No. 4. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for HC Yellow 4 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is HC Yellow 4 used outside industrial chemicals?

HC Yellow 4 also appears in cosmetics, pharmaceutical databases.