What is the NOAEL for L-Leucine?
L-Leucine has 7 NOAEL studies in the database. The lowest reported value is 293.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
L-Leucine
Also known as: Leucine, L-, L-2-Amino-4-methylpentanoic acid, Leu, L-(-)-2-Amino-4-methylpentanoic acid, 2-Amino-4-methylpentanoic acid, (S)- (+15 more)
CAS 61-90-5
L-Leucine (CAS 61-90-5) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
L-Leucine
CAS Number
61-90-5
DTXSID
DTXSID9023203
Molecular Formula
C6H13NO2
InChI Key
ROHFNLRQFUQHCH-YFKPBYRVSA-N
Monoisotopic Mass
131.094629
Synonyms
Leucine, L-L-2-Amino-4-methylpentanoic acidLeuL-(-)-2-Amino-4-methylpentanoic acid2-Amino-4-methylpentanoic acid, (S)-EINECS 200-522-0FEMA No. 3297Valeric acid, 2-amino-4-methyl-, (S)-LeucinaLeucinumUNII-GMW67QNF9C(2S)-2-Amino-4-methylpentanoate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
7 records
Anti-static agentSoftener and conditionerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | US International Trade Commission | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =293.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| GMW67QNF9C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 5000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 7000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 7200 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 8000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | L-leucine | 200-522-0 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
LEUCINE
ChEMBL Phase
3
Adverse Events
8
Bioactivity
4
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
2 records
E641 — ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw | FDA GRAS: FDA has no questions
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Leucine?
L-Leucine appears on 4 regulatory/inventory lists including Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), pharmaceutical, and 1 more. Source: EPA CPDat.
Is L-Leucine used in cosmetics?
Yes, L-Leucine is also indexed as a cosmetic ingredient under the name L-Leucine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Leucine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is L-Leucine used outside industrial chemicals?
L-Leucine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.