What is the NOAEL for Malic Acid?
Malic Acid has 9 NOAEL studies in the database. The lowest reported value is 817L1N4CKP UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Malic Acid
CAS 617-48-1
Malic Acid (CAS 617-48-1) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, ECHA REACH.
Cross-Vertical Regulatory Divergence
Malic Acid is classified GHS Danger (H302, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
9
SOURCE
Chemical inventory jurisdictions
Regulatory lists
0
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
2 fields
Name
Malic Acid
CAS Number
617-48-1
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 817L1N4CKP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 817L1N4CKP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 817L1N4CKP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 817L1N4CKP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 40 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 200 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 266 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 350 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1400 | mg/kg bw/day | NOAEL | oral | dog | COSMOS DB |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | DL-malic acid | 210-514-9 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Frequently Asked Questions
Is Malic Acid used in cosmetics?
Yes, Malic Acid is also indexed as a cosmetic ingredient under the name Malic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Malic Acid come from?
Safety data is sourced from EPA ToxValDB, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does Malic Acid have different safety status in cosmetics vs industrial chemicals?
Malic Acid is classified GHS Danger (H302, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Is Malic Acid used outside industrial chemicals?
Malic Acid also appears in cosmetics databases.