What is the NOAEL for Cremophor EL?
Cremophor EL has 20 NOAEL studies in the database. The lowest reported value is 16.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Cremophor EL
Also known as: Castor oil, ethoxylated, Cremophor EL Castor Oil, POLYOXYETHYLENE CASTOR ETHE, OILS, POLYOXY ETHYLATED CASTOR, OILS, CASTOR, ETHOXYLATED (+15 more)
CAS 61791-12-6
Cremophor EL (CAS 61791-12-6) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
20
SOURCE
chemical inventory jurisdictions
Regulatory lists
12
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Cremophor EL
CAS Number
61791-12-6
DTXSID
DTXSID2047696
Synonyms
Castor oil, ethoxylatedCremophor EL Castor OilPOLYOXYETHYLENE CASTOR ETHEOILS, POLYOXY ETHYLATED CASTOROILS, CASTOR, ETHOXYLATEDCaster oil ethoxylatedPEG 200 castor oilPEG 75 castor oilEC No.: 500-151-7CremaphorEmulphor EL-620Polyoxyethylated castor oil
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Cleaning agentSurfactant (surface active agent)Softener and conditionerEmulsifierProcessing aids not otherwise specified
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
12 records
| List | Keyword | Source |
|---|---|---|
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| fracking; water | NY Department of Conservation | CPCat |
| consumer_product | P&G | Proctor & Gamble |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 20 of 20 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =16.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 4ERD2076EF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4ERD2076EF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4ERD2076EF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4ERD2076EF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6D4M1DAL6O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6D4M1DAL6O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6D4M1DAL6O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6D4M1DAL6O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GF873K38RZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GF873K38RZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GF873K38RZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GF873K38RZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VXP26NM2XX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VXP26NM2XX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VXP26NM2XX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VXP26NM2XX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =46.25 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| =480 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 20 of 20 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Castor oil, ethoxylated | 500-151-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
Frequently Asked Questions
What regulatory lists include Cremophor EL?
Cremophor EL appears on 8 regulatory/inventory lists including SCIL (9/2019), Indirect additives food contact (10/2018), inert_ingredient; Pesticides, and 5 more. Source: EPA CPDat.
Is Cremophor EL used in cosmetics?
Yes, Cremophor EL is also indexed as a cosmetic ingredient under the name PEG-3 Castor Oil. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Cremophor EL come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is Cremophor EL used outside industrial chemicals?
Cremophor EL also appears in cosmetics databases.