What is the NOAEL for 4-Hydroxybenzenemethanol?
4-Hydroxybenzenemethanol has 48 NOAEL studies in the database. The lowest reported value is 0.5 mg/kg bw/day. Source: INCHEM_WHO_jecfa_jecmono_v48je15.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-Hydroxybenzenemethanol
Also known as: EINECS 210-768-0, UNII-1A3AH1FP1B, 4-(Hydroxymethyl)phenol (ACD/Name 4.0), B4-hydroxy-enzenemethanol, a-Hydroxy-p-cresol (+2 more)
CAS 623-05-2
4-Hydroxybenzenemethanol (CAS 623-05-2) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
48
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
4-Hydroxybenzenemethanol
CAS Number
623-05-2
DTXSID
DTXSID8073920
Molecular Formula
C7H8O2
InChI Key
BVJSUAQZOZWCKN-UHFFFAOYSA-N
Monoisotopic Mass
124.052429
Synonyms
EINECS 210-768-0UNII-1A3AH1FP1B4-(Hydroxymethyl)phenol (ACD/Name 4.0)B4-hydroxy-enzenemethanola-Hydroxy-p-cresolalpha-Hydroxy-p-cresolp-Hydroxy-Benzyl alcohol
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
3 records
Softener and conditionerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 48 of 48 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =0.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =2.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =2.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =3 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =3 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =10 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =10 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| 1A3AH1FP1B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1A3AH1FP1B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1A3AH1FP1B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1A3AH1FP1B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =0.008 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =0.008 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =0.028 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =0.028 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =0.1 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =0.1 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =0.9 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =0.9 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =4.7 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =4.7 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =7.3 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =7.3 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =50 | mg/kg bw/day | NOEL | - | Dog | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =50 | mg/kg bw/day | NOEL | - | Dog | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =94 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =94 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =100 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =100 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =170 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =170 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =250 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =250 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =450 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =450 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =500 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =500 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =900 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =900 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =1000 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =1000 | mg/kg bw/day | NOEL | - | Rat | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =2000 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =2000 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =2500 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
| =2500 | mg/kg bw/day | NOEL | - | - | INCHEM_WHO_jecfa_jecmono_v48je15 |
Showing 48 of 48 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-hydroxybenzyl alcohol | 210-768-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PARAHYDROXYBENZYL ALCOHOL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 4-Hydroxybenzenemethanol?
4-Hydroxybenzenemethanol appears on 2 regulatory/inventory lists including Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is 4-Hydroxybenzenemethanol used in cosmetics?
Yes, 4-Hydroxybenzenemethanol is also indexed as a cosmetic ingredient under the name Hydroxybenzyl Alcohol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Hydroxybenzenemethanol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 4-Hydroxybenzenemethanol used outside industrial chemicals?
4-Hydroxybenzenemethanol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.