What is the NOAEL for Lactose?
Lactose has 14 NOAEL studies in the database. The lowest reported value is 3SY5LH9PMK UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Lactose
Also known as: D-(+)-Lactose, Galactinum, Lactose anhydrous, Tablettose, 4-O-beta-D-Galactopyranosyl-beta-D-glucopyranose (+10 more)
CAS 63-42-3
Lactose (CAS 63-42-3) is a chemical substance. Key regulatory status: 22 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
22
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
Lactose
CAS Number
63-42-3
DTXSID
DTXSID2023193
Molecular Formula
C12H22O11
InChI Key
GUBGYTABKSRVRQ-DCSYEGIMSA-N
Monoisotopic Mass
342.116212
Synonyms
D-(+)-LactoseGalactinumLactose anhydrousTablettose4-O-beta-D-Galactopyranosyl-beta-D-glucopyranosebeta-D-Glucopyranose, 4-O-beta-D-galactopyranosyl-β-D-Glucopyranose, 4-O-β-D-galactopyranosyl-4-O-β-D-Galactopyranosyl-β-D-glucopyranose4-17-00-03066BRN 0093796EINECS 200-559-24-(beta-D-Galactosido)-D-glucose
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
16 records
HumectantSoftener and conditionerFragranceFlavouring and nutrientProcessing aids not otherwise specifiedSolventThickening agentSurfactant (surface active agent)Lubricating agentOxidizing agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
22 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| supplements | Danish EPA | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| fracking; water | NY Department of Conservation | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 3SY5LH9PMK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3SY5LH9PMK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3SY5LH9PMK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3SY5LH9PMK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >10000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 5250 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 10000 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 12500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 15000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 20950 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 24868 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 35000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 82500 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
Showing 14 of 14 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Humectant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
lactose
ChEMBL Phase
Not listed
Adverse Events
182
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Lactose?
Lactose appears on 11 regulatory/inventory lists including inert_ingredient; Pesticides, IFRA Transparency, Canada; consumer_product; Substances in Products - Canada (4/2014), and 8 more. Source: EPA CPDat.
Is Lactose used in cosmetics?
Yes, Lactose is also indexed as a cosmetic ingredient under the name Lactose. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Lactose come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Lactose used outside industrial chemicals?
Lactose also appears in cosmetics, pharmaceutical, food safety, cannabis databases.