What is the NOAEL for 2-Isobutyl-4-methyltetrahydropyran-4-ol?
2-Isobutyl-4-methyltetrahydropyran-4-ol has 11 NOAEL studies in the database. The lowest reported value is 44.1 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Isobutyl-4-methyltetrahydropyran-4-ol
Also known as: 4-Methyl-2-(2-methylpropyl)tetrahydro-2H-pyran-4-ol, 2H-Pyran-4-ol, tetrahydro-4-methyl-2-(2-methylpropyl)-, A mixture of: cis-Tetrahydro-2-isobutyl-4-methylpyran-4-ol; trans-Tetrahydro-2-isobutyl-4-methylpyran-4-ol, 2-(Isobutyl)-4-hydroxy-4-methyl tetrahydropyran, Florol
CAS 63500-71-0
2-Isobutyl-4-methyltetrahydropyran-4-ol (CAS 63500-71-0) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Isobutyl Methyl Tetrahydropyranol →
SOURCE
NOAEL studies
NOAEL studies
11
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
2-Isobutyl-4-methyltetrahydropyran-4-ol
CAS Number
63500-71-0
Molecular Formula
C10H20O2
InChI Key
YVSNOTITPICPTB-UHFFFAOYSA-N
Monoisotopic Mass
172.14633
Synonyms
4-Methyl-2-(2-methylpropyl)tetrahydro-2H-pyran-4-ol2H-Pyran-4-ol, tetrahydro-4-methyl-2-(2-methylpropyl)-A mixture of: cis-Tetrahydro-2-isobutyl-4-methylpyran-4-ol; trans-Tetrahydro-2-isobutyl-4-methylpyran-4-ol2-(Isobutyl)-4-hydroxy-4-methyl tetrahydropyranFlorol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceDeodorizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =44.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| VK5ZHH2T3F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 4408 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| =10 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =125 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =1000 | mg/kg bw/day | NOAEL | dermal | Rat | ECHA |
| =4000 | ppm | NOAEL | oral | Rat | ECHA |
| =1.250e+4 | ppm | NOAEL | oral | Rat | ECHA |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| 4 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | A mixture of: cis-tetrahydro-2-isobutyl-4-methylpyran-4-ol; trans-tetrahydro-2-isobutyl-4-methylpyran-4-ol | 405-040-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Frequently Asked Questions
What regulatory lists include 2-Isobutyl-4-methyltetrahydropyran-4-ol?
2-Isobutyl-4-methyltetrahydropyran-4-ol appears on 3 regulatory/inventory lists including IFRA Transparency, consumer_product, SCIL (9/2019). Source: EPA CPDat.
Is 2-Isobutyl-4-methyltetrahydropyran-4-ol used in cosmetics?
Yes, 2-Isobutyl-4-methyltetrahydropyran-4-ol is also indexed as a cosmetic ingredient under the name Isobutyl Methyl Tetrahydropyranol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Isobutyl-4-methyltetrahydropyran-4-ol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-Isobutyl-4-methyltetrahydropyran-4-ol used outside industrial chemicals?
2-Isobutyl-4-methyltetrahydropyran-4-ol also appears in cosmetics databases.