What is the GHS hazard classification for Ethanol?
Ethanol (CAS 64-17-5) is classified under EU CLP Annex VI as Flam. Liq. 2 with signal word Danger. Hazard statements: H225. Source: EU CLP Annex VI (ECHA).
Danger
GHS02
NOAEL Data
IARC Group 1
REACH Registered
Cosmetic Ingredient
Ethanol
Also known as: Ethyl alcohol, EtOH, Alcohol, anhydrous, Alcohol dehydrated, Alcohol, diluted (+15 more)
CAS 64-17-5
Ethanol (CAS 64-17-5) is a chemical substance with GHS signal word Danger; key hazard signal: H225. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, IARC, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Ethanol is classified GHS Danger (H225) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
78
SOURCE
Chemical inventory jurisdictions
Regulatory lists
60
SOURCE
EU CLP Annex VI
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
25 fields
Name
Ethanol
CAS Number
64-17-5
Molecular Formula
C2H6O
InChI Key
LFQSCWFLJHTTHZ-UHFFFAOYSA-N
Monoisotopic Mass
46.041865
Synonyms
Ethyl alcoholEtOHAlcohol, anhydrousAlcohol dehydratedAlcohol, dilutedAlcohol, ethylCaswell No. 430Denatured alcohol CD-10Denatured alcohol CD-5Denatured alcohol CD-5aDenatured alcohol SD-1Denatured alcohol SD-13a
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 1 | Carcinogenic to humans | 2009 | 96, 100E |
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2 | H225 | GHS02 | Danger |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
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WHO/JECFA
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Highly flammable liquid and vapour Harmful if swallowed Causes serious eye irritation May cause damage to organs through prolonged or repeated exposure |
| Short-term Effects | The substance is severely irritating to the eyes. The vapour at high levels is irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the upper respiratory tract and central nervous system. This may result in irritation, headache, fatigue and lack of concentration. See Notes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour and by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
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OSHA / NIOSH / ACGIH occupational exposure limits
8 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 1000 ppm (1900 mg/m³) | 1000 | 1900 | N |
| NIOSH | TWA | 1000 ppm (1900 mg/m³) | 1000 | 1900 | N |
| ACGIH | STEL | 1000 ppm [2008] | 1000 | - | N |
| CAL/OSHA | TWA | 1000 ppm (1900 mg/m³) | 1000 | 1900 | N |
| NIOSH | IDLH | 3300 ppm | 3300 | - | - |
| AIHA | ERPG-1 | 1800 ppm | 1800 | - | - |
| AIHA | ERPG-2 | 3300 ppm | 3300 | - | - |
| AIHA | ERPG-3 | -- | - | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
60 records
SolventBiocideDrierAstringent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care; Europe | Danish EPA | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Road vehicles | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 78 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 19.98 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 31.1 | uL/min/10^6 cells | Clint | - | Rat | NTP ICE adme parameters |
| =380 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| =950 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 24 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP ICE eye irritation |
| 1 | unitless | EPA Classification | Ocular | Rabbit | NTP ICE eye irritation |
| 4 | unitless | EPA Classification | Inhalation | - | NTP ICE acute inhalation |
| 4 | unitless | EPA classification | Dermal | Rat | NTP ICE acute dermal |
| =4 | Unitless | EPA classification | oral | Rat (Female) | NTP ICE acute oral |
| 4 | unitless | EPA classification | Dermal | Rabbit | NTP ICE skin irritation |
| 3K9958V90M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7528N5H79B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| 0.842 | fraction | Fu | - | Rat | NTP ICE adme parameters |
| 0.9338 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP ICE eye irritation |
| 5 | unitless | GHS classification | Dermal | Rat | NTP ICE acute dermal |
| =5 | Unitless | GHS classification | oral | Rat (Female) | NTP ICE acute oral |
| 1 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 1 | unitless | IARC group | - | - | NTP ICE cancer |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 6.299e+4 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 0.12 | %/sec | Intensity | Ocular | - | NTP ICE eye irritation |
| 2.16 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 5.9 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 37.66 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 51.3 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 52.9 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 54.8 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 116.9 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 124.7 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 133.8 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| >5000 | mg/kg bw | LD50 | oral | Rat (Female) | NTP ICE acute oral |
| >5050 | mg/kg | LD50 | Dermal | Rat | NTP ICE acute dermal |
| =6200 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =7060 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =7400 | mg/kg bw | LD50 | oral | Rat (Male) | NTP ICE acute oral |
| >7692 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =9900 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1.034e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1.047e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1.060e+4 | mg/kg bw | LD50 | oral | Rat (Male) | NTP ICE acute oral |
| =1.120e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1.150e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1.240e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1.366e+4 | mg/kg bw | LD50 | oral | Rat (Male) | NTP ICE acute oral |
| =1.501e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1.554e+4 | mg/kg bw | LD50 | oral | Rat (Male) | NTP ICE acute oral |
| =1.775e+4 | mg/kg bw | LD50 | oral | Rat (Male) | NTP ICE acute oral |
| =1.780e+4 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
Showing 50 of 78 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ethanol | 200-578-6 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
ALCOHOL
ChEMBL Phase
4
Adverse Events
1495
Bioactivity
8
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: LIMITED BY GMP (use as solvent, 1970) mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Ethanol?
Ethanol has 78 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.
What regulatory lists include Ethanol?
Ethanol appears on 25 regulatory/inventory lists including Arts and crafts/Office supplies - fabric treatment and dye; detected, Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe, consumer_product; detected; Europe, and 22 more. Source: EPA CPDat.
Is Ethanol a carcinogen according to IARC?
Ethanol is classified by IARC as Group 1 — carcinogenic to humans (evaluated 2009). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
What are the occupational exposure limits for Ethanol?
Occupational exposure limits for Ethanol are set by OSHA, NIOSH, ACGIH. 8 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Ethanol used in cosmetics?
Yes, Ethanol is also indexed as a cosmetic ingredient under the name Alcohol Denat. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ethanol come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Ethanol have different safety status in cosmetics vs industrial chemicals?
Ethanol is classified GHS Danger (H225) in the chemicals database but is allowed in EU cosmetics.
Is Ethanol used outside industrial chemicals?
Ethanol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.