What is the NOAEL for Aminotrimethylene phosphonic acid?
Aminotrimethylene phosphonic acid has 14 NOAEL studies in the database. The lowest reported value is 9.7 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Aminotrimethylene phosphonic acid
Also known as: Phosphonic acid, [nitrilotris(methylene)]tris-, 4-01-00-03070, Aminotri(methylene phosphonic acid), BRN 1715724, EINECS 229-146-5 (+3 more)
CAS 6419-19-8
Aminotrimethylene phosphonic acid (CAS 6419-19-8) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Aminotrimethylene Phosphonic Acid →
SOURCE
noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Aminotrimethylene phosphonic acid
CAS Number
6419-19-8
DTXSID
DTXSID2027624
Molecular Formula
C3H12NO9P3
InChI Key
YDONNITUKPKTIG-UHFFFAOYSA-N
Monoisotopic Mass
298.972492
Synonyms
Phosphonic acid, [nitrilotris(methylene)]tris-4-01-00-03070Aminotri(methylene phosphonic acid)BRN 1715724EINECS 229-146-5Nitrilotrimethylenephosphonic acid(Nitrilotris(methylene))trisphosphonic acidUNII-1Y702GD0FG
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
Chelating agentStabilizing agentOxidizing agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 14.3 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| 15.1 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| =9.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 1Y702GD0FG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1Y702GD0FG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1Y702GD0FG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1Y702GD0FG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >=500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=576 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >1000 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =3000 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =10000 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3.2 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
| 7.9 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
Showing 14 of 14 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Nitrilotrimethylenetris(phosphonic acid) | 229-146-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
NITRILOTRI(METHYLPHOSPHONIC ACID)
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Aminotrimethylene phosphonic acid?
Aminotrimethylene phosphonic acid appears on 2 regulatory/inventory lists including SCIL (9/2019), inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.
Is Aminotrimethylene phosphonic acid used in cosmetics?
Yes, Aminotrimethylene phosphonic acid is also indexed as a cosmetic ingredient under the name Aminotrimethylene Phosphonic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Aminotrimethylene phosphonic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Aminotrimethylene phosphonic acid used outside industrial chemicals?
Aminotrimethylene phosphonic acid also appears in cosmetics, pharmaceutical databases.