Danger GHS02GHS06GHS08 NOAEL Data Prop 65 REACH Registered Cosmetic Ingredient

Methanol

Also known as: Alcohol, methyl, Caswell No. 552, X-Cide 402 Industrial Bactericide, Colonial spirits, EINECS 200-659-6 (+15 more)

CAS 67-56-1

Methanol (CAS 67-56-1) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H331; H311; H301; H370 **. Key regulatory status: California Proposition 65, REACH registered, 18 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Methyl Alcohol →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
18
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields
Name
Methanol
CAS Number
67-56-1
DTXSID
DTXSID2021731
Molecular Formula
CH4O
InChI Key
OKKJLVBELUTLKV-UHFFFAOYSA-N
Monoisotopic Mass
32.026215
Synonyms
Alcohol, methylCaswell No. 552X-Cide 402 Industrial BactericideColonial spiritsEINECS 200-659-6EPA Pesticide Chemical Code 053801Eureka Products, CriosineEureka Products Criosine DisinfectantFreers Elm ArresterIdeal Concentrated Wood PreservativeMethyl hydratePyroxylic spirits

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records
ChemicalToxicity TypeCancerDevelopmentalListed
-developmentalNoYes-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Flam. Liq. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT SE 1H225; H331; H311; H301; H370 **GHS02; GHS06; GHS08Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
GHS Signal WordDANGER
GHS Hazard StatementsHighly flammable liquid and vapour Toxic if swallowed Harmful if inhaled Causes damage to central nervous system
Short-term EffectsThe substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. This may result in loss of consciousness. Exposure could cause blindness and death. The effects may be delayed. Medical observation is indicated.
Long-term EffectsRepeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the central nervous system. This may result in persistent or recurring headaches and impaired vision.
Routes of ExposureThe substance can be absorbed into the body by inhalation, through the skin and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 12 records
AgencyMetricValueppmmg/m3Skin
OSHATWA200 ppm (260 mg/m³)200260N
NIOSHTWA200 ppm (260 mg/m³)200260Y
NIOSHSTEL250 ppm (325 mg/m³)250325Y
ACGIHTWA200 ppm [2008]200-Y
ACGIHSTEL250 ppm [2008]250-Y
CAL/OSHATWA200 ppm (260 mg/m³)200260Y
CAL/OSHASTEL250 ppm (325 mg/m³)250325Y
CAL/OSHACEILING1000 ppm1000-Y
NIOSHIDLH6000 ppm6000--
AIHAERPG-1200 ppm200--
AIHAERPG-21000 ppm1000--
AIHAERPG-35000 ppm5000--

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
SolventFragranceSurfactant (surface active agent)Corrosion inhibitorThickening agentAnti-slip agentChemical reaction regulatorDegradant/impurityProcessing aids not otherwise specifiedCleaning agentNo specific technical functionAdhesion/cohesion promoter

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 18 records
ListKeywordSource
drinking_water; Europe; manufacturing; plastic_additiveBelgaquaCPCat
inert_ingredient; non_food_use; PesticidesEPACPCat
consumer_product; detectedElsevierCPCat
consumer_product; EuropeDanish Environmental Protection AgencyDanish EPA
consumer_product; EuropeDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Personal careElsevierCPCat
air; Cleaning products and household care - air freshener; detected; emissionsElsevierCPCat
OEHHA Proposition 65 (3/2019)STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCYOEHHA Proposition 65 List
Europe; Home maintenance - caulk/sealantDanish Environmental Protection AgencyDanish EPA
Europe; Home maintenance - caulk/sealantDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Home maintenance - caulk/sealantDanish Environmental Protection AgencyDanish EPA
detected; Europe; Home maintenance - caulk/sealantDanish Environmental Protection AgencyDanish EPA
Europe; Personal care; restrictedEuropean CommissionCosIng
frackingFracFocusFracFocus
consumer_productP&GProctor & Gamble
fracking; waterNY Department of ConservationCPCat
OEHHA Proposition 65 (1/2023)California Office of Environmental Health Hazard AssessmentOEHHA Proposition 65 List
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
=399.708mg/m3BMC (05)inhalationMouseToxValDB_Cal_OEHHA_REL_derivations
=43.1mg/LBMDL (05)oralMouseToxValDB_IRIS
=858mg-hr/LBMDL (1SD)inhalationRatToxValDB_IRIS
=43.1mg/LBMDL 05 (INTERNAL)inhalation-EPA_IRIS_iris_rfd_systems.csv
=858mg-hr/LBMDL 1SD (INTERNAL)inhalation-EPA_IRIS_iris_rfc_systems.csv
ABinhalation=47000; oral=23000ug/dayCalifornia Proposition 65 MADL--California Proposition 65
ABinhalation=47000; oral=23000ug/dayCalifornia Proposition 65 MADL--California Proposition 65
ABinhalation=47000; oral=23000ug/dayCalifornia Proposition 65 MADL--California Proposition 65
ABinhalation=47000; oral=23000ug/dayCalifornia Proposition 65 MADL--California Proposition 65
ABdevelopmentallisting typeCalifornia Proposition 65 listing--California Proposition 65
ABdevelopmentallisting typeCalifornia Proposition 65 listing--California Proposition 65
ABdevelopmentallisting typeCalifornia Proposition 65 listing--California Proposition 65
ABdevelopmentallisting typeCalifornia Proposition 65 listing--California Proposition 65
0.8866uL/min/10^6 cellsClint-HumanNTP_ICE_adme_parameters
3.837uL/min/10^6 cellsClint-RatNTP_ICE_adme_parameters
=130mg/m3DNEL localinhalationHumanToxValDB_GESTIS_DNEL
Y4S76JWI15UNIIFDA UNII substance identifier--openFDA substances
Y4S76JWI15UNIIFDA UNII substance identifier--openFDA substances
Y4S76JWI15UNIIFDA UNII substance identifier--openFDA substances
Y4S76JWI15UNIIFDA UNII substance identifier--openFDA substances
0.9449fractionFu-HumanNTP_ICE_adme_parameters
0.9505fractionFu-RatNTP_ICE_adme_parameters
83.8205mg/LLC50Inhalation-NTP_ICE_acute_inhalation
87.6187mg/LLC50Inhalation-NTP_ICE_acute_inhalation
128.2192mg/LLC50Inhalation-NTP_ICE_acute_inhalation
189.9059mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=5628mg/kg bwLD50oralRatNTP_ICE_acute_oral
=6200mg/kg bwLD50oralRatNTP_ICE_acute_oral
=7400mg/kg bwLD50oralRat (Male)NTP_ICE_acute_oral
=7914mg/kg bwLD50oralRatNTP_ICE_acute_oral
=8000mg/kg bwLD50oralRatNTP_ICE_acute_oral
=9100mg/kg bwLD50oralRat (Male)NTP_ICE_acute_oral
=10283mg/kg bwLD50oralRat (Male)NTP_ICE_acute_oral
=11303mg/kg bwLD50oralRatNTP_ICE_acute_oral
=12880mg/kg bwLD50oralRat (Male)NTP_ICE_acute_oral
=12900mg/kg bwLD50oralRatNTP_ICE_acute_oral
=72078.5mg/m3LELinhalationHumanToxValDB_DOE_Protective_Action_Criteria
=2000mg/kg bw/dayLOAECinjectionRabbitToxValDB_ECHA_IUCLID
=6650mg/m3LOAECinhalationMouseToxValDB_ECHA_IUCLID
=13105.2mg/m3LOAECinhalationMouseToxValDB_ECHA_IUCLID
=250mg/kg bw/dayLOAELoralRatToxValDB_DOE_Wildlife_Benchmarks
=601.528mg/m3LOAELinhalationHumanToxValDB_TX_TCEQ
=1310.52mg/m3LOAELinhalationPrimateToxValDB_HPVIS
>1800mg/kg bw/dayLOAELoralMouseToxValDB_ECHA_IUCLID
<2100mg/kg bw/dayLOAELoralMouseToxValDB_ECHA_IUCLID
=2340mg/kg bw/dayLOAELoralMonkeyToxValDB_ECHA_IUCLID
=2500mg/kg bw/dayLOAELoralRatToxValDB_HPVIS
=2621.04mg/m3LOAELinhalationMouseToxValDB_HPVIS
=5000mg/kg bw/dayLOAELoralMouseToxValDB_ECHA_IUCLID
=6552.59mg/m3LOAELinhalationRatToxValDB_HPVIS

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredMethanol200-659-6ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records
ChemicalCategoryFlags
Methanol--

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
5%
Category
Fragrance
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL METHYL ALCOHOL
ChEMBL Phase
-1
Adverse Events
48
Bioactivity
2
View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Methanol?

Methanol (CAS 67-56-1) is classified under EU CLP Annex VI as Flam. Liq. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT SE 1 with signal word Danger. Hazard statements: H225; H331; H311; H301; H370 **. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Methanol?

Methanol has 100 NOAEL studies in the database. The lowest reported value is 0.001 mg via injection in Mouse. Source: ToxValDB_ECOTOX.

What regulatory lists include Methanol?

Methanol appears on 16 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, inert_ingredient; non_food_use; Pesticides, consumer_product; detected, and 13 more. Source: EPA CPDat.

Is Methanol on the California Proposition 65 list?

Yes, Methanol is listed under California Proposition 65 for developmental. Source: California OEHHA Proposition 65.

What are the occupational exposure limits for Methanol?

Occupational exposure limits for Methanol are set by OSHA, NIOSH, ACGIH. 12 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Methanol used in cosmetics?

Yes, Methanol is also indexed as a cosmetic ingredient under the name Methyl Alcohol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Methanol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Methanol have different safety status in cosmetics vs industrial chemicals?

Methanol is classified GHS Danger (H225, H331, H311, H301, H370) in the chemicals database but is restricted in EU cosmetics at max 5%.

Is Methanol used outside industrial chemicals?

Methanol also appears in cosmetics, pharmaceutical, cannabis databases.