NOAEL Data REACH Registered Cosmetic Ingredient

Dimethyl sulfoxide

Also known as: Methyl sulfoxide, DMSO, Methane, sulfinylbis-, Caswell No. 381, Demasorb (+15 more)

CAS 67-68-5

Dimethyl sulfoxide (CAS 67-68-5) is a chemical substance. Key regulatory status: REACH registered, 14 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.

View cosmetic safety profile for DMSO (Dimethyl Sulfoxide) →

Cross-Vertical Regulatory Divergence

Dimethyl sulfoxide is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335, H227, H371).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

Dimethyl sulfoxide

CAS Number

67-68-5

Molecular Formula

C2H6OS

InChI Key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

Monoisotopic Mass

78.013936

Synonyms

Methyl sulfoxideDMSOMethane, sulfinylbis-Caswell No. 381DemasorbDoligurEINECS 200-664-3EPA Pesticide Chemical Code 000177MethylsulfinylmethaneNSC-763Dimethyli sulfoxidumDimetilsolfossido

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records

Field	Value
GHS Signal Word	WARNING
GHS Hazard Statements	Combustible liquid
Short-term Effects	The substance is mildly irritating to the eyes and skin. Exposure to high concentrations could cause lowering of consciousness. May accelerate skin absorption of other materials. See Notes.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 7 records

SolventFlavouring and nutrientFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 14 records

List	Keyword	Source
active_ingredient; Australia	Australian Pesticides and Veterinary Medicines Authority	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
pharmaceutical	US International Trade Commission	CPCat
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
Canada; pharmaceutical	DrugBank	DrugBank
banned; Europe; Personal care	European Commission	CosIng
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 67 studies

Value	Unit	Endpoint	Route	Species	Source
4895	ug/mL	CD54, EC200	Dermal	-	NTP ICE skin sensitization
>200	ug/mL	CD86, EC150	Dermal	-	NTP ICE skin sensitization
5000	ug/mL	CV75	Dermal	-	NTP ICE skin sensitization
=17.67	mg/m3	DNEL local	inhalation	Human	ToxValDB GESTIS DNEL
=75	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
7.3	unitless	Draize rabbit irritation score	Ocular	Rabbit	NTP ICE eye irritation
>2000	uM	EC1.5	Dermal	-	NTP ICE skin sensitization
72	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
3	unitless	EPA Classification	Ocular	Rabbit	NTP ICE eye irritation
YOW8V9698H	UNII	FDA UNII substance identifier	-	-	openFDA substances
1.23	ratio	Imax	Dermal	-	NTP ICE skin sensitization
0	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
4.655e+4	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
0.11	%/sec	Intensity	Ocular	-	NTP ICE eye irritation
=1.450e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=2.830e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1800	mg/kg bw/day	LEL	injection	Mouse	ECHA
=8.308e+4	mg/m3	LEL	inhalation	Human	ToxValDB DOE Protective Action Criteria
=2.783	mg/L	LOAEC	inhalation	Rat	ToxValDB HPVIS
=5380	mg/m3	LOAEC	inhalation	Rat	ECHA
=660	mg/kg bw/day	LOAEL	dermal	Dog	ECHA
=750	mg/kg bw/day	LOAEL	injection	Rat	ECHA
=990	mg/kg bw/day	LOAEL	dermal	Monkey	ECHA
=1650	mg/kg bw/day	LOAEL	dermal	Rabbit	ECHA
=2000	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB HPVIS
=2500	mg/kg bw/day	LOAEL	oral	Dog	ToxValDB HPVIS
=2970	mg/kg bw/day	LOAEL	dermal	Pig	ECHA
=4950	mg/kg bw/day	LOAEL	dermal	Rabbit	ECHA
=5000	mg/kg bw/day	LOAEL	dermal	Rabbit	ECHA
=8910	mg/kg bw/day	LOAEL	oral	Monkey	ECHA
=9900	mg/kg bw/day	LOAEL	oral	Rat	ECHA
=1.100e+4	mg/kg bw/day	LOAEL	dermal	Monkey	ECHA
=25	uL	LOEL	dermal	Mouse	ToxValDB ECOTOX
>180	s	Lag time	Ocular	-	NTP ICE eye irritation
0	unitless	Model Score	-	-	NTP ICE endocrine
=0.2	mg/L	NOAEC	inhalation	Rat	ToxValDB HPVIS
=0.964	mg/L	NOAEC	inhalation	Rat	ToxValDB HPVIS
=964	mg/m3	NOAEC	inhalation	Rat	ECHA
=1390	mg/m3	NOAEC	inhalation	Rat	ECHA
=2783	mg/m3	NOAEC	inhalation	Rat	ECHA
=2793	mg/m3	NOAEC	inhalation	Rat	ECHA
>2800	mg/m3	NOAEC	inhalation	Rat	ECHA
<300	mg/kg bw/day	NOAEL	injection	Dog	ECHA
=500	mg/kg bw/day	NOAEL	injection	Rat	ECHA
=825	mg/kg bw/day	NOAEL	dermal	Pig	ECHA
=1000	mg/kg bw/day	NOAEL	oral	Rabbit	ECHA
=1000	mg/kg bw/day	NOAEL	oral	Rat	EFSA
=1000	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA
=1100	mg/kg bw/day	NOAEL	dermal	Dog	ECHA
=1100	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB HPVIS

Showing 50 of 67 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Dimethyl sulfoxide	200-664-3	ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed DIMETHYL SULFOXIDE

ChEMBL Phase

Adverse Events

149

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Dimethyl sulfoxide?

Dimethyl sulfoxide has 67 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.

What regulatory lists include Dimethyl sulfoxide?

Dimethyl sulfoxide appears on 9 regulatory/inventory lists including active_ingredient; Australia, inert_ingredient; non_food_use; Pesticides, pharmaceutical, and 6 more. Source: EPA CPDat.

Is Dimethyl sulfoxide used in cosmetics?

Yes, Dimethyl sulfoxide is also indexed as a cosmetic ingredient under the name DMSO (Dimethyl Sulfoxide). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Dimethyl sulfoxide come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Dimethyl sulfoxide have different safety status in cosmetics vs industrial chemicals?

Dimethyl sulfoxide is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335, H227, H371).

Is Dimethyl sulfoxide used outside industrial chemicals?

Dimethyl sulfoxide also appears in cosmetics, pharmaceutical, food safety, cannabis databases.