NOAEL Data REACH Registered Cosmetic Ingredient

Dimethyl sulfoxide

Also known as: Methyl sulfoxide, DMSO, Methane, sulfinylbis-, Caswell No. 381, Demasorb (+15 more)

CAS 67-68-5

Dimethyl sulfoxide (CAS 67-68-5) is a chemical substance. Key regulatory status: REACH registered, 14 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.

View cosmetic safety profile for DMSO (Dimethyl Sulfoxide) →

Cross-Vertical Regulatory Divergence

Dimethyl sulfoxide is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335, H227, H371).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Dimethyl sulfoxide

CAS Number

67-68-5

DTXSID

DTXSID2021735

Molecular Formula

C2H6OS

InChI Key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

Monoisotopic Mass

78.013936

Synonyms

Methyl sulfoxideDMSOMethane, sulfinylbis-Caswell No. 381DemasorbDoligurEINECS 200-664-3EPA Pesticide Chemical Code 000177MethylsulfinylmethaneNSC-763Dimethyli sulfoxidumDimetilsolfossido

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	WARNING
GHS Hazard Statements	Combustible liquid
Short-term Effects	The substance is mildly irritating to the eyes and skin. Exposure to high concentrations could cause lowering of consciousness. May accelerate skin absorption of other materials. See Notes.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 7 records

SolventFlavouring and nutrientFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 14 records

List	Keyword	Source
active_ingredient; Australia	Australian Pesticides and Veterinary Medicines Authority	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
pharmaceutical	US International Trade Commission	CPCat
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
Canada; pharmaceutical	DrugBank	DrugBank
banned; Europe; Personal care	European Commission	CosIng
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 71 studies

Value	Unit	Endpoint	Route	Species	Source
4894.5	ug/mL	CD54, EC200	Dermal	-	NTP_ICE_skin_sensitization
>200	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
5000	ug/mL	CV75	Dermal	-	NTP_ICE_skin_sensitization
=17.67	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
=75	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
7.3	unitless	Draize rabbit irritation score	Ocular	Rabbit	NTP_ICE_eye_irritation
>2000	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
72	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
3	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
YOW8V9698H	UNII	FDA UNII substance identifier	-	-	openFDA substances
YOW8V9698H	UNII	FDA UNII substance identifier	-	-	openFDA substances
YOW8V9698H	UNII	FDA UNII substance identifier	-	-	openFDA substances
YOW8V9698H	UNII	FDA UNII substance identifier	-	-	openFDA substances
1.23	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
46550	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
0.11	%/sec	Intensity	Ocular	-	NTP_ICE_eye_irritation
=14500	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=28300	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=1800	mg/kg bw/day	LEL	injection	Mouse	ToxValDB_ECHA_IUCLID
=83083.4	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=2.783	mg/L	LOAEC	inhalation	Rat	ToxValDB_HPVIS
=5380	mg/m3	LOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=660	mg/kg bw/day	LOAEL	dermal	Dog	ToxValDB_ECHA_IUCLID
=750	mg/kg bw/day	LOAEL	injection	Rat	ToxValDB_ECHA_IUCLID
=990	mg/kg bw/day	LOAEL	dermal	Monkey	ToxValDB_ECHA_IUCLID
=1650	mg/kg bw/day	LOAEL	dermal	Rabbit	ToxValDB_ECHA_IUCLID
=2000	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_HPVIS
=2500	mg/kg bw/day	LOAEL	oral	Dog	ToxValDB_HPVIS
=2970	mg/kg bw/day	LOAEL	dermal	Pig	ToxValDB_ECHA_IUCLID
=4950	mg/kg bw/day	LOAEL	dermal	Rabbit	ToxValDB_ECHA_IUCLID
=5000	mg/kg bw/day	LOAEL	dermal	Rabbit	ToxValDB_ECHA_IUCLID
=8910	mg/kg bw/day	LOAEL	oral	Monkey	ToxValDB_ECHA_IUCLID
=9900	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=11000	mg/kg bw/day	LOAEL	dermal	Monkey	ToxValDB_ECHA_IUCLID
=25	uL	LOEL	dermal	Mouse	ToxValDB_ECOTOX
>180	s	Lag time	Ocular	-	NTP_ICE_eye_irritation
-	unitless	Model Score	-	-	NTP_ICE_endocrine
=0.2	mg/L	NOAEC	inhalation	Rat	ToxValDB_HPVIS
=0.964	mg/L	NOAEC	inhalation	Rat	ToxValDB_HPVIS
=964	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=1390	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=2783	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=2793	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
>2800	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
<300	mg/kg bw/day	NOAEL	injection	Dog	ToxValDB_ECHA_IUCLID
=500	mg/kg bw/day	NOAEL	injection	Rat	ToxValDB_ECHA_IUCLID
=825	mg/kg bw/day	NOAEL	dermal	Pig	ToxValDB_ECHA_IUCLID
=1000	mg/kg bw/day	NOAEL	oral	Rabbit	ToxValDB_ECHA_IUCLID
=1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA

Showing 50 of 71 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Dimethyl sulfoxide	200-664-3	ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL DIMETHYL SULFOXIDE

ChEMBL Phase

Adverse Events

149

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Dimethyl sulfoxide?

Dimethyl sulfoxide has 71 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include Dimethyl sulfoxide?

Dimethyl sulfoxide appears on 9 regulatory/inventory lists including active_ingredient; Australia, inert_ingredient; non_food_use; Pesticides, pharmaceutical, and 6 more. Source: EPA CPDat.

Is Dimethyl sulfoxide used in cosmetics?

Yes, Dimethyl sulfoxide is also indexed as a cosmetic ingredient under the name DMSO (Dimethyl Sulfoxide). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Dimethyl sulfoxide come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Dimethyl sulfoxide have different safety status in cosmetics vs industrial chemicals?

Dimethyl sulfoxide is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335, H227, H371).

Is Dimethyl sulfoxide used outside industrial chemicals?

Dimethyl sulfoxide also appears in cosmetics, pharmaceutical, food safety, cannabis databases.