What is the NOAEL for 2-Hexene, 1,1-diethoxy-, (2E)-?
2-Hexene, 1,1-diethoxy-, (2E)- has 22 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
Cosmetic Ingredient
2-Hexene, 1,1-diethoxy-, (2E)-
CAS 67746-30-9
2-Hexene, 1,1-diethoxy-, (2E)- (CAS 67746-30-9) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
View cosmetic safety profile for Hexadienal Diethyl Acetal →
Cross-Vertical Regulatory Divergence
2-Hexene, 1,1-diethoxy-, (2E)- is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H315, H317, H319).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
22
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
6 fields
Name
2-Hexene, 1,1-diethoxy-, (2E)-
CAS Number
67746-30-9
DTXSID
DTXSID50886871
Molecular Formula
C10H20O2
InChI Key
WMQKYHTZGYIHHD-CMDGGOBGSA-N
Monoisotopic Mass
172.14633
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| banned; Europe; Personal care | European Commission | CosIng |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 22 of 22 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.625 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1.486 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 12 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.5 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 1.143 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 8 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 1UMD1RAR3Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1UMD1RAR3Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1UMD1RAR3Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1UMD1RAR3Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3.333 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 26.92 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 64 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 5400 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 421.875 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1003 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 8100 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 337.5 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 771.4 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 22 of 22 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include 2-Hexene, 1,1-diethoxy-, (2E)-?
2-Hexene, 1,1-diethoxy-, (2E)- appears on 3 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), banned; Europe; Personal care, consumer_product. Source: EPA CPDat.
Is 2-Hexene, 1,1-diethoxy-, (2E)- used in cosmetics?
Yes, 2-Hexene, 1,1-diethoxy-, (2E)- is also indexed as a cosmetic ingredient under the name Hexadienal Diethyl Acetal. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Hexene, 1,1-diethoxy-, (2E)- come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Hexene, 1,1-diethoxy-, (2E)- have different safety status in cosmetics vs industrial chemicals?
2-Hexene, 1,1-diethoxy-, (2E)- is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H315, H317, H319).
Is 2-Hexene, 1,1-diethoxy-, (2E)- used outside industrial chemicals?
2-Hexene, 1,1-diethoxy-, (2E)- also appears in cosmetics, food safety databases.