Also known as: 1H-3a,7-Methanoazulene, octahydro-6-methoxy-3,6,8,8-tetramethyl-, [3R-(3α,3aβ,6α,7β,8aα)]-
CAS 67874-81-1
1H-3a,7-Methanoazulene, octahydro-6-methoxy-3,6,8,8-tetramethyl-, (3R,3aS,6R,7R,8aS)- (CAS 67874-81-1) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for OCTAHYDRO-METHOXY-TETRAMETHYL-METHANOAZULENE →
CAS, identifiers, formula, and alternate names for the matched substance record.
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =16.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 84S7T555CV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 84S7T555CV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 84S7T555CV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 84S7T555CV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 5400 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| >=330 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| >=406 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 10 of 10 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | [3R-(3α,3aβ,6α,7β,8aα)]-octahydro-6-methoxy-3,6,8,8-tetramethyl-1H-3a,7-methanoazulene | 267-510-5 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
1H-3a,7-Methanoazulene, octahydro-6-methoxy-3,6,8,8-tetramethyl-, (3R,3aS,6R,7R,8aS)- has 10 NOAEL studies in the database. The lowest reported value is 16.1 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
1H-3a,7-Methanoazulene, octahydro-6-methoxy-3,6,8,8-tetramethyl-, (3R,3aS,6R,7R,8aS)- appears on 1 regulatory/inventory list including IFRA Transparency. Source: EPA CPDat.
Yes, 1H-3a,7-Methanoazulene, octahydro-6-methoxy-3,6,8,8-tetramethyl-, (3R,3aS,6R,7R,8aS)- is also indexed as a cosmetic ingredient under the name OCTAHYDRO-METHOXY-TETRAMETHYL-METHANOAZULENE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
1H-3a,7-Methanoazulene, octahydro-6-methoxy-3,6,8,8-tetramethyl-, (3R,3aS,6R,7R,8aS)- also appears in cosmetics databases.