What is the NOAEL for Piroctone olamine?
Piroctone olamine has 36 NOAEL studies in the database. The lowest reported value is 12.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Piroctone olamine
Also known as: EINECS 272-574-2, Octopirox, UNII-A4V5C6R9FB, Kopirox
CAS 68890-66-4
Piroctone olamine (CAS 68890-66-4) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Piroctone olamine is classified GHS Danger (H315, H318, H335, H400, H410, H412) in the chemicals database but is restricted in EU cosmetics at max 1.0% rinse-off / 0.5% leave-on.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
36
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
Piroctone olamine
CAS Number
68890-66-4
DTXSID
DTXSID4046735
Molecular Formula
C14H23NO2.C3H9NO
InChI Key
UVVPSBVBVDDOSR-UHFFFAOYSA-N
Monoisotopic Mass
312.241293
Synonyms
EINECS 272-574-2OctopiroxUNII-A4V5C6R9FBKopirox
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
PreservativeBiocide
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 36 of 36 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =12.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =14.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| A4V5C6R9FB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A4V5C6R9FB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A4V5C6R9FB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A4V5C6R9FB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =225 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1 | % | NOAEL | dermal | human | SCCNFP_vision_codex |
| =1 | % | NOAEL | dermal | human | SCCNFP_vision_codex |
| =1 | % | NOAEL | dermal | human | SCCNFP_vision_codex |
| =1 | % | NOAEL | dermal | human | SCCNFP_vision_codex |
| =16 | mg/kg/day | NOAEL | oral | rat | SCCNFP_vision_codex |
| =16 | mg/kg/day | NOAEL | oral | rat | SCCNFP_vision_codex |
| =16 | mg/kg/day | NOAEL | oral | rat | SCCNFP_vision_codex |
| =16 | mg/kg/day | NOAEL | oral | rat | SCCNFP_vision_codex |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg/day | NOAEL | oral | rat | SCCNFP_vision_codex |
| =100 | mg/kg/day | NOAEL | oral | rat | SCCNFP_vision_codex |
| =100 | mg/kg/day | NOAEL | oral | rat | SCCNFP_vision_codex |
| =100 | mg/kg/day | NOAEL | oral | rat | SCCNFP_vision_codex |
| =225 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| <2000 | mg/kg bw/day | NOAEL | injection | Rat | ToxValDB_ECHA_IUCLID |
| >=2 | mg/cm2-day | NOEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| >=55 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >63 | mg/kg bw/day | NOEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| >=100 | mg/cm2-day | NOEL | dermal | Rabbit | ToxValDB_ECHA_IUCLID |
| >=100 | mg/kg bw/day | NOEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| >=210 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=500 | mg/kg bw/day | NOEL | injection | Rat | ToxValDB_ECHA_IUCLID |
| >=2000 | mg/kg bw/day | NOEL | injection | Rat | ToxValDB_ECHA_IUCLID |
| 1 | % | dermal absorption | dermal | human | UnifiedCodex:SCCNFP:beta.noael_studies |
| 1 | % | dermal absorption | dermal | human | UnifiedCodex:SCCNFP:beta.noael_studies |
| 1 | % | dermal absorption | dermal | human | UnifiedCodex:SCCNFP:beta.noael_studies |
| 16 | mg/kg/day | developmental toxicity | oral | rat | UnifiedCodex:SCCNFP:beta.noael_studies |
| 100 | mg/kg/day | developmental toxicity | oral | rat | UnifiedCodex:SCCNFP:beta.noael_studies |
Showing 36 of 36 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1) | 272-574-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
1.0% rinse-off / 0.5% leave-on
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PIROCTONE OLAMINE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Piroctone olamine?
Piroctone olamine appears on 2 regulatory/inventory lists including active_ingredient; Europe; Pesticides, Europe; Personal care - hair styling and care - shampoo-dandruff. Source: EPA CPDat.
Is Piroctone olamine used in cosmetics?
Yes, Piroctone olamine is also indexed as a cosmetic ingredient under the name Piroctone Olamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Piroctone olamine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Piroctone olamine have different safety status in cosmetics vs industrial chemicals?
Piroctone olamine is classified GHS Danger (H315, H318, H335, H400, H410, H412) in the chemicals database but is restricted in EU cosmetics at max 1.0% rinse-off / 0.5% leave-on.
Is Piroctone olamine used outside industrial chemicals?
Piroctone olamine also appears in cosmetics, pharmaceutical databases.