What is the NOAEL for Delta-Octanolactone?
Delta-Octanolactone has 11 NOAEL studies in the database. The lowest reported value is 8AA944C37V UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Delta-Octanolactone
Also known as: 2H-Pyran-2-one, tetrahydro-6-propyl-, delta-Octalactone, 5-17-09-00068, BRN 0111515, EINECS 211-820-5 (+8 more)
CAS 698-76-0
Delta-Octanolactone (CAS 698-76-0) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Delta-Octanolactone
CAS Number
698-76-0
DTXSID
DTXSID5047164
Molecular Formula
C8H14O2
InChI Key
FYTRVXSHONWYNE-UHFFFAOYSA-N
Monoisotopic Mass
142.09938
Synonyms
2H-Pyran-2-one, tetrahydro-6-propyl-delta-Octalactone5-17-09-00068BRN 0111515EINECS 211-820-5FEMA No. 32145-Hydroxyoctanoic acid lactone5-OctalactoneOctanoic acid, 5-hydroxy-, lactone5-Octanolide5-Propyl-5-hydroxypentanoic acid lactonedelta-Propyl-delta-valerolactone
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
13 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 8AA944C37V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8AA944C37V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8AA944C37V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8AA944C37V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 8100 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =112 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =112 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =112 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Tetrahydro-6-propyl-2H-pyran-2-one | 211-820-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3182050
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Delta-Octanolactone?
Delta-Octanolactone appears on 3 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Delta-Octanolactone used in cosmetics?
Yes, Delta-Octanolactone is also indexed as a cosmetic ingredient under the name Delta-Octalactone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Delta-Octanolactone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Delta-Octanolactone used outside industrial chemicals?
Delta-Octanolactone also appears in cosmetics, pharmaceutical, cannabis databases.