NOAEL Data REACH Registered Cosmetic Ingredient

1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione

Also known as: 1,3-Propanedione, 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-, 1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedione, EINECS 274-581-6, Avobenzona, Avobenzonum (+2 more)

CAS 70356-09-1

1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione (CAS 70356-09-1) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Avobenzone →

SOURCE noael studies public
NOAEL studies
10
SOURCE chemical inventory jurisdictions
Regulatory lists
6
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields
Name
1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione
CAS Number
70356-09-1
DTXSID
DTXSID9044829
Molecular Formula
C20H22O3
InChI Key
XNEFYCZVKIDDMS-UHFFFAOYSA-N
Monoisotopic Mass
310.156895
Synonyms
1,3-Propanedione, 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedioneEINECS 274-581-6AvobenzonaAvobenzonumUNII-G63QQF2NOXBMDBM

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 39 records
UV stabilizerFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records
ListKeywordSource
Europe; Personal careEuropean CommissionCosIng
IFRA TransparencyIFRAIFRA
pharmaceuticalUS International Trade CommissionCPCat
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
Canada; consumer_product; Substances in Products - Canada (4/2014)Government of CanadaCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 10 of 10 studies
ValueUnitEndpointRouteSpeciesSource
G63QQF2NOXUNIIFDA UNII substance identifier--openFDA substances
G63QQF2NOXUNIIFDA UNII substance identifier--openFDA substances
G63QQF2NOXUNIIFDA UNII substance identifier--openFDA substances
G63QQF2NOXUNIIFDA UNII substance identifier--openFDA substances
>16000mg/kg bwLD50oralRatNTP_ICE_acute_oral
=100mg/kg bw/dayLOAELdermalRabbitToxValDB_ECHA_IUCLID
=1000mg/kg bw/dayLOAELoralRatToxValDB_ECHA_IUCLID
=360mg/kg bw/dayNOAELdermalRabbitToxValDB_ECHA_IUCLID
=450mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=1000mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID

Showing 10 of 10 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)propane-1,3-dione274-581-6ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
5%
Category
active
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL AVOBENZONE
ChEMBL Phase
4
Adverse Events
95
Bioactivity
4
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione?

1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione has 10 NOAEL studies in the database. The lowest reported value is G63QQF2NOX UNII. Source: openFDA substances.

What regulatory lists include 1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione?

1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione appears on 5 regulatory/inventory lists including Europe; Personal care, IFRA Transparency, pharmaceutical, and 2 more. Source: EPA CPDat.

Is 1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione used in cosmetics?

Yes, 1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione is also indexed as a cosmetic ingredient under the name Avobenzone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione used outside industrial chemicals?

1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione also appears in cosmetics, pharmaceutical databases.