What is the NOAEL for L-Threonine?
L-Threonine has 8 NOAEL studies in the database. The lowest reported value is 158 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
L-Threonine
Also known as: 2-Amino-3-hydroxybutanoic acid, (R-(R*,S*))-, Butanoic acid, 2-amino-3-hydroxy-, (R-(R*,S*))-, EINECS 200-774-1, Threoninum, Treonina (+10 more)
CAS 72-19-5
L-Threonine (CAS 72-19-5) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
L-Threonine
CAS Number
72-19-5
DTXSID
DTXSID2046412
Molecular Formula
C4H9NO3
InChI Key
AYFVYJQAPQTCCC-GBXIJSLDSA-N
Monoisotopic Mass
119.058243
Synonyms
2-Amino-3-hydroxybutanoic acid, (R-(R*,S*))-Butanoic acid, 2-amino-3-hydroxy-, (R-(R*,S*))-EINECS 200-774-1ThreoninumTreoninaUNII-2ZD004190S(2S)-threonine(2S,3R)-(-)-Threonine(2S,3R)-2-Amino-3-hydroxybutyric acid(2S,3R)-2-amino-3-hydroxy-butanoic acid(2S,3R)-2-amino-3-hydroxybutanoic acid(R-(R*,S*))-2-Amino-3-hydroxybutanoic acid
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Flavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =158 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 2ZD004190S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2ZD004190S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2ZD004190S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2ZD004190S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >5.15 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >5.22 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 3000 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | L-threonine | 200-774-1 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
amino_acid
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
THREONINE
ChEMBL Phase
2
Adverse Events
36
Bioactivity
2
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Threonine?
L-Threonine appears on 2 regulatory/inventory lists including pharmaceutical, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is L-Threonine used in cosmetics?
Yes, L-Threonine is also indexed as a cosmetic ingredient under the name L-Threonine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Threonine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is L-Threonine used outside industrial chemicals?
L-Threonine also appears in cosmetics, pharmaceutical, cannabis databases.