What is the NOAEL for Silicon?
Silicon has 4 NOAEL studies in the database. The lowest reported value is Z4152N8IUI UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Silicon
Also known as: Defoamer S-10, EINECS 231-130-8, UNII-Z4152N8IUI, 14Si, Si (+3 more)
CAS 7440-21-3
Silicon (CAS 7440-21-3) is a chemical substance. Key regulatory status: REACH registered, 21 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Silicon is classified GHS Danger (H228, H320) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
21
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Silicon
CAS Number
7440-21-3
DTXSID
DTXSID0051441
Molecular Formula
Si
InChI Key
XUIMIQQOPSSXEZ-UHFFFAOYSA-N
Monoisotopic Mass
27.976927
Synonyms
Defoamer S-10EINECS 231-130-8UNII-Z4152N8IUI14SiSiSiliziumsiliciosilicon atom
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | May cause mechanical irritation to the eyes and respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
3 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 15 mg/m³ (total dust), 5 mg/m³ (respirable fraction) | - | 15 | N |
| NIOSH | TWA | 10 mg/m³ (total dust), 5 mg/m³ (resp) | - | 10 | N |
| CAL/OSHA | TWA | 10 mg/m³ (total dust), 5 mg/m³ (respirable fraction) | - | 10 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
AbrasiveFillerDegradant/impurity
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
21 records
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Home maintenance - caulk/sealant | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; supplements | EU | CPCat |
| detected; Europe; Personal care - make-up and related - eye liner | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| Z4152N8IUI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z4152N8IUI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z4152N8IUI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Z4152N8IUI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Silicon | 231-130-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ChEMBL Phase
Not listed
Adverse Events
7
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Silicon?
Silicon appears on 9 regulatory/inventory lists including detected; Europe; Home maintenance - caulk/sealant, Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe, detected; Europe; Other direct contact consumer goods, and 6 more. Source: EPA CPDat.
What are the occupational exposure limits for Silicon?
Occupational exposure limits for Silicon are set by OSHA, NIOSH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Silicon used in cosmetics?
Yes, Silicon is also indexed as a cosmetic ingredient under the name Silicon (Elemental). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Silicon come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Silicon have different safety status in cosmetics vs industrial chemicals?
Silicon is classified GHS Danger (H228, H320) in the chemicals database but is allowed in EU cosmetics.
Is Silicon used outside industrial chemicals?
Silicon also appears in cosmetics, pharmaceutical, cannabis databases.