What is the NOAEL for Chromium?
Chromium has 12 NOAEL studies in the database. The lowest reported value is 0.5 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Chromium
Also known as: BioChrome, BioChrome (feed additive), Chrome, Dinakrome, Sun Ti-Cr (+8 more)
CAS 7440-47-3
Chromium (CAS 7440-47-3) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 35 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA, EPA TRI.
Cross-Vertical Regulatory Divergence
Chromium is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H319, H334, H320, H335, H341, H371, H400).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
12
SOURCE
Chemical inventory jurisdictions
Regulatory lists
35
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Chromium
CAS Number
7440-47-3
Molecular Formula
Cr
InChI Key
VYZAMTAEIAYCRO-UHFFFAOYSA-N
Monoisotopic Mass
51.940506
Synonyms
BioChromeBioChrome (feed additive)ChromeDinakromeSun Ti-CrChromcromoUN 1759EINECS 231-157-5UNII-0R0008Q3JB24CrCr
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1989 | Sup 7, 49 |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | May cause mechanical irritation to the eyes and respiratory tract. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
15 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 0.5 mg/m³ | - | 0.5 | N |
| NIOSH | TWA | 0.5 mg/m³ | - | 0.5 | N |
| ACGIH | TWA | 0.5 mg/m³ (inhalable particulate matter) [2017] | - | 0.5 | N |
| CAL/OSHA | TWA | 0.5 mg/m³ | - | 0.5 | N |
| NIOSH | IDLH | 250 mg/m³ | - | 250 | - |
| OSHA | TWA | 0.5 mg/m³ | - | 0.5 | N |
| NIOSH | TWA | 0.5 mg/m³ | - | 0.5 | N |
| ACGIH | TWA | 0.003 mg/m³ (inhalable particulate matter) [2017] | - | 0.003 | N |
| CAL/OSHA | TWA | 0.5 mg/m³ | - | 0.5 | N |
| NIOSH | IDLH | 250 mg/m³ | - | 250 | - |
| OSHA | TWA | 1 mg/m³ | - | 1 | N |
| NIOSH | TWA | 0.5 mg/m³ | - | 0.5 | N |
| ACGIH | TWA | 0.5 mg/m³ (inhalable particulate matter) [2017] | - | 0.5 | N |
| CAL/OSHA | TWA | 0.5 mg/m³ | - | 0.5 | N |
| NIOSH | IDLH | 250 mg/m³ | - | 250 | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
DyeDegradant/impurity
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
35 records
| List | Keyword | Source |
|---|---|---|
| Europe; supplements | EU | CPCat |
| detected; Europe; Personal care - make-up and related - eye liner | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Israel; Toys and children's products | Chemosphere | Published Articles |
| - | Environmental Research | Published Articles |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| Canada; pharmaceutical | DrugBank | DrugBank |
| fracking; water | NY Department of Conservation | CPCat |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| banned; Europe; Personal care | European Commission | CosIng |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - children's art and toys - crayons; detected; Toys and children's products | Journal of Environmental Science and Health | Published Articles |
| detected; Toys and children's products | Environmental Science & Technology | Published Articles |
| detected; Toys and children's products | Environmental Science & Technology | Published Articles |
| detected; Toys and children's products | Environmental Science & Technology | Published Articles |
| Arts and crafts/Office supplies - children's art and toys; Arts and crafts/Office supplies - children's art and toys - crayons; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; Toys and children's products | Environmental Science & Technology | Published Articles |
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.5 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| 0R0008Q3JB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP ICE cancer |
| =0.0144 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB ECOTOX |
| =0.39 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB ECOTOX |
| =5 | mg/L | LOEL | oral | Rat | ToxValDB ECOTOX |
| =14.8 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB ECOTOX |
| =20 | mg/L | LOEL | oral | Rat | ToxValDB ECOTOX |
| =0.0432 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB ECOTOX |
| =0.003 | mg/kg bw/day | RfD | oral | Human | ToxValDB OW Drinking Water Standards |
| =0.001 | mg/kg bw/day | TDI | oral | Human | ToxValDB Health Canada |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Chromium | 231-157-5 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| Chromium | - | - |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
ChEMBL Phase
Not listed
Adverse Events
235
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Chromium?
Chromium appears on 14 regulatory/inventory lists including Europe; supplements, detected; Europe; Personal care - make-up and related - eye liner, Arts and crafts/Office supplies - body paint; detected; Europe, and 11 more. Source: EPA CPDat.
Is Chromium a carcinogen according to IARC?
Chromium is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1989). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
What are the occupational exposure limits for Chromium?
Occupational exposure limits for Chromium are set by OSHA, NIOSH, ACGIH. 15 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Chromium used in cosmetics?
Yes, Chromium is also indexed as a cosmetic ingredient under the name Chromium. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Chromium come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Chromium have different safety status in cosmetics vs industrial chemicals?
Chromium is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H319, H334, H320, H335, H341, H371, H400).
Is Chromium used outside industrial chemicals?
Chromium also appears in cosmetics, pharmaceutical databases.