What is the GHS hazard classification for Copper?
Copper (CAS 7440-50-8) is classified under EU CLP Annex VI as Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H400; H410. Source: EU CLP Annex VI (ECHA).
Warning
GHS09
NOAEL Data
REACH Registered
Cosmetic Ingredient
Copper
Also known as: Copper (Cu), Copper foil, M1, M3, M4 (+15 more)
CAS 7440-50-8
Copper (CAS 7440-50-8) is a chemical substance with GHS signal word Warning; key hazard signal: H400; H410. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ILO ICSC, EPA TRI.
SOURCE
noael studies public
NOAEL studies
26
SOURCE
chemical inventory jurisdictions
Regulatory lists
60
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Copper
CAS Number
7440-50-8
DTXSID
DTXSID2023985
Molecular Formula
Cu
InChI Key
RYGMFSIKBFXOCR-UHFFFAOYSA-N
Monoisotopic Mass
62.929598
Synonyms
Copper (Cu)Copper foilM1M3M4Caswell No. 227CI Pigment metal 2Copper bronzeCopper slag-airborneCopper slag-milledCopper-airborneCopper-milled
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Aquatic Acute 1; Aquatic Chronic 1 | H400; H410 | GHS09 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Flammable solid Harmful if swallowed Very toxic to aquatic life with long lasting effects |
| Short-term Effects | Inhalation of fumes may cause metal fume fever. See Notes. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. Ingestion may cause effects on the liver. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
PigmentDyeSolvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - general arts and crafts supplies; Europe | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| Europe; supplements | EU | CPCat |
| detected; Europe; Personal care - make-up and related - eye liner | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 26 of 26 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1.3 | - | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =0.05 | mg/kg bw/day | BMDL (10) | oral | Human | ToxValDB_ATSDR_MRLs |
| 789U1901C5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 789U1901C5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 789U1901C5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =5.3 | mg | LOAEL | oral | Human | ToxValDB_HEAST |
| =7 | mg/day | LOAEL | oral | Human | ToxValDB_Copper_Manufacturers |
| =50 | mg/kg bw/day | LOEC | oral | Rat | ToxValDB_ECOTOX |
| =117 | mg/kg bw/day | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =0.02 | mg/kg bw/day | MRL | oral | Human | ToxValDB_ATSDR_MRLs |
| =0.02 | mg/kg bw/day | MRL | oral | Human | ToxValDB_ATSDR_MRLs |
| =1 | mg Cu/m3 | NOAEL | inhalation | Human | ToxValDB_Cal_OEHHA_REL_derivations |
| =1.3 | - | NOAEL | oral | rat | SCCS_vision_codex |
| =1.3 | - | NOAEL | oral | rat | SCCS_vision_codex |
| =1.3 | - | NOAEL | oral | rat | SCCS_vision_codex |
| =1.3 | - | NOAEL | oral | rat | SCCS_vision_codex |
| =10 | mg/day | NOAEL | oral | Human | ToxValDB_Health_Canada |
| =10 | mg/day | NOAEL | - | Human | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
| =10 | mg/day | NOAEL | - | Human | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
| =100 | mg/kg bw/day | NOEC | oral | Rat | ToxValDB_ECOTOX |
| =200 | mg/kg bw/day | NOEC | oral | Rat | ToxValDB_ECOTOX |
| =24 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =100 | ppm | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =250 | ppm | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =1.3 | mg/L | RfC | oral | Human | ToxValDB_HEAST |
| =0.04 | mg/kg bw/day | RfD | oral | Human | ToxValDB_Copper_Manufacturers |
Showing 26 of 26 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Copper | 231-159-6 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| Copper | - | - |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1621/20 | 5 March 2021 | insufficient data | Not determined | Limited/missing essential information; possible systemic uptake with accumulation in liver/spleen; potential mutagenic/genotoxic and immunotoxic/nephrotoxic effects; basis for concern |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
2%
Category
colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ChEMBL Phase
Not listed
Adverse Events
1271
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
2 records
FDA GRAS: FDA has no questions
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Copper?
Copper has 26 NOAEL studies in the database. The lowest reported value is 0.05 mg/kg bw/day via oral in Human. Source: ToxValDB_ATSDR_MRLs.
What regulatory lists include Copper?
Copper appears on 18 regulatory/inventory lists including pharmaceutical, Personal care, active_ingredient; Pesticides, and 15 more. Source: EPA CPDat.
Is Copper used in cosmetics?
Yes, Copper is also indexed as a cosmetic ingredient under the name Bronze Powder (CI 77400). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Copper come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Copper used outside industrial chemicals?
Copper also appears in cosmetics, pharmaceutical, food safety, cannabis databases.