What is the GHS hazard classification for Dichloromethane?
Dichloromethane (CAS 75-09-2) is classified under EU CLP Annex VI as Carc. 2 with signal word Warning. Hazard statements: H351. Source: EU CLP Annex VI (ECHA).
Warning
GHS08
NOAEL Data
IARC Group 2A
Prop 65
REACH Registered
Cosmetic Ingredient
Dichloromethane
Also known as: Methane, dichloro-, Methylene chloride, 4-01-00-00035, BRN 1730800, Caswell No. 568 (+15 more)
CAS 75-09-2
Dichloromethane (CAS 75-09-2) is a chemical substance with GHS signal word Warning; key hazard signal: H351. Key regulatory status: California Proposition 65, REACH registered, 23 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, SCCS, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.
Cross-Vertical Regulatory Divergence
Dichloromethane is prohibited in EU cosmetics but has active industrial GHS classifications (H351).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
85
SOURCE
Chemical inventory jurisdictions
Regulatory lists
23
SOURCE
EU CLP Annex VI
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Dichloromethane
CAS Number
75-09-2
Molecular Formula
CH2Cl2
InChI Key
YMWUJEATGCHHMB-UHFFFAOYSA-N
Monoisotopic Mass
83.953355
Synonyms
Methane, dichloro-Methylene chloride4-01-00-00035BRN 1730800Caswell No. 568EINECS 200-838-9EPA Pesticide Chemical Code 042004Methylenum chloratumNCI-C50102RCRA waste number U080UNII-588X2YUY0AAerothene
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2A | Probably carcinogenic | 2014 | Sup 7, 71, 110 |
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Carc. 2 | H351 | GHS08 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Harmful if swallowed Fatal if inhaled Causes skin and eye irritation May cause drowsiness or dizziness Causes damage to central nervous system, blood, liver, the heart and lungs May be harmful if swallowed and enters airways Causes damage to the central nervous system through prolonged or repeated exposure if inhaled May cause cancer |
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. The substance may cause effects on the central nervous system, blood, liver, heart and lungs. Exposure could cause carbon monoxide poisoning. This may result in impaired functions. Exposure at high concentrations could cause lowering of consciousness and death. The effects may be delayed. |
| Long-term Effects | The substance may have effects on the central nervous system. This substance is probably carcinogenic to humans. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, by ingestion and through the skin. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
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OSHA / NIOSH / ACGIH occupational exposure limits
9 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 25 ppm [12.5 ppm Action Level] | 25 | - | Y |
| OSHA | STEL | 125 ppm | 125 | - | Y |
| ACGIH | TWA | 50 ppm [1997] | 50 | - | N |
| CAL/OSHA | TWA | 25 ppm (87 mg/m³) | 25 | 87 | N |
| CAL/OSHA | STEL | 125 ppm (435 mg/m³) | 125 | 435 | N |
| NIOSH | IDLH | 2300 ppm | 2300 | - | - |
| AIHA | ERPG-1 | 300 ppm | 300 | - | - |
| AIHA | ERPG-2 | 750 ppm | 750 | - | - |
| AIHA | ERPG-3 | 4000 ppm | 4000 | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
11 records
SolventAdhesion/cohesion promoterFlavouring and nutrientDye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
23 records
| List | Keyword | Source |
|---|---|---|
| air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| banned; Europe; Personal care | European Commission | CosIng |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| consumer_product; detected | Elsevier | CPCat |
| consumer_product; Europe; nondetect | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| air; detected; emissions; Packaging (non-food contact) | Reproductive Toxicology | Published Articles |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| children; WA Children's Safe Product Act (4/2020) | State of Washington Department of Ecology | State of Washington |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| children | Vermont Department of Health | State of Vermont |
| children | Oregon Health Authority | State of Oregon |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 85 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =17.2 | mg/m3 | BMDL (HEC) | inhalation | Rat | ToxValDB IRIS |
| =0.19 | mg/kg bw/day | BMDL (HED) | oral | Rat | ToxValDB IRIS |
| =17.2 | mg/m^3 | BMDL 10 (HEC) | inhalation | - | Regulatory source |
| =0.19 | mg/kg/day | BMDL 10 (HED) | oral | - | Regulatory source |
| SQEinhalation=200 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 13.72 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 74.39 | uL/min/10^6 cells | Clint | - | Rat | NTP ICE adme parameters |
| =176 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 588X2YUY0A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.3875 | fraction | Fu | - | Rat | NTP ICE adme parameters |
| 0.7057 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 2A | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP ICE cancer |
| 1.000e-8 | ug/m3 | Inhalation risk unit | Inhalation | - | NTP ICE cancer |
| 52 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 52.04 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 74.74 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 76 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 197.9 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =500 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB EPA TSCA 8e |
| =1000 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB EPA TSCA 8e |
| =1500 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB EPA TSCA 8e |
| =2000 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB EPA TSCA 8e |
| =8684 | mg/m3 | LEL | inhalation | Dog | ToxValDB EPA TSCA 8e |
| =4.516e+5 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| =3474 | mg/m3 | LOAEC | inhalation | Rat | ECHA |
| =1.770e+4 | mg/m3 | LOAEC | inhalation | Rat | ECHA |
| =0.3 | mg/kg bw/day | LOAEL | oral: unspecified | Common quail | EFSA |
| =0.6 | mg/kg bw/day | LOAEL | oral: feed | Black duck | EFSA |
| =16 | mg/kg bw/day | LOAEL | oral | Human | ToxValDB ATSDR MRLs |
| =16 | mg/kg/day | LOAEL | oral | Human (M/F) | Regulatory source |
| 50 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| =50 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB DOE Wildlife Benchmarks |
| 55 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| =64 | mg/kg bw/day | LOAEL | oral | Mouse | ECHA |
| =86.84 | mg/m3 | LOAEL | inhalation | Rat (Not Specified; unknown) | Regulatory source |
| =138.9 | mg/m3 | LOAEL | inhalation | Human | ToxValDB Cal OEHHA REL derivations |
| 250 | mg/kg bw/day | LOAEL | oral | mouse | COSMOS DB |
| =320 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| =677.4 | mg/m3 | LOAEL | inhalation | Human | ToxValDB Cal OEHHA REL derivations |
| =1042 | mg/m3 | LOAEL | inhalation | Human | ToxValDB ATSDR MRLs |
| =1042 | mg/m3 | LOAEL | inhalation | Human (M/F) | Regulatory source |
| =86.84 | mg/m3 | LOAEL (HEC) | inhalation | Rat | ToxValDB ATSDR MRLs |
| =0.05 | mg/kg bw/day | LOEL | oral: feed | Chicken | EFSA |
| =115 | mg/kg bw/day | LOEL | injection | Rat | ToxValDB ECOTOX |
| =333 | mg/kg bw/day | LOEL | oral | Mouse | ECHA |
| =1720 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB ECOTOX |
| =7100 | mg/m3 | LOEL | inhalation | - | WHO/JECFA |
| =0.2 | mg/kg bw/day | MRL | oral | Human | ToxValDB ATSDR MRLs |
Showing 50 of 85 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | dichloromethane; methylene chloride | 200-838-9 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| Dichloromethane (Methylene chloride) | - | - |
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
2 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1547/15 | 28 October 2015 | not safe (hair sprays) | 0.2% maximum impurity; 35% in hair sprays NOT safe | CMR category 2; carcinogenic by inhalation in mice; inadequate data on neurobehavioural and neurodevelopmental effects after short-term exposure by hair spraying; no new data provided in Submission IV |
| SCCS/1488/12 | 11 December 2012 | 35% in hair sprays not safe | CMR 2 carcinogen by inhalation; inadequate neurobehavioural/neurodevelopmental data for short-term inhalation exposure; neurotoxicity concerns |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
METHYLENE CHLORIDE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
2
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Dichloromethane?
Dichloromethane has 85 NOAEL studies in the database. The lowest reported value is 1.000e-8 ug/m3 via Inhalation. Source: NTP ICE cancer.
What regulatory lists include Dichloromethane?
Dichloromethane appears on 19 regulatory/inventory lists including air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe, air; detected; emissions; Europe; Toys and children's products, air; detected; emissions; Europe; Other direct contact consumer goods, and 16 more. Source: EPA CPDat.
Is Dichloromethane a carcinogen according to IARC?
Dichloromethane is classified by IARC as Group 2A — probably carcinogenic to humans (evaluated 2014). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Dichloromethane on the California Proposition 65 list?
Yes, Dichloromethane is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
What are the occupational exposure limits for Dichloromethane?
Occupational exposure limits for Dichloromethane are set by OSHA, ACGIH, CAL/OSHA. 9 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Dichloromethane used in cosmetics?
Yes, Dichloromethane is also indexed as a cosmetic ingredient under the name Methylene Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dichloromethane come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Dichloromethane have different safety status in cosmetics vs industrial chemicals?
Dichloromethane is prohibited in EU cosmetics but has active industrial GHS classifications (H351).
Is Dichloromethane used outside industrial chemicals?
Dichloromethane also appears in cosmetics, pharmaceutical, cannabis databases.