What is the NOAEL for Trisodium phosphate?
Trisodium phosphate has 13 NOAEL studies in the database. The lowest reported value is 4.07 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Trisodium phosphate
Also known as: Caswell No. 898, EINECS 231-509-8, Emulsiphos 440/660, EPA Pesticide Chemical Code 076406, NSC 215202 (+13 more)
CAS 7601-54-9
Trisodium phosphate (CAS 7601-54-9) is a chemical substance. Key regulatory status: REACH registered, 39 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Trisodium phosphate is classified GHS Danger (H315, H319, H335, H314, H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
13
SOURCE
Chemical inventory jurisdictions
Regulatory lists
39
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
Trisodium phosphate
CAS Number
7601-54-9
DTXSID
DTXSID2035223
Molecular Formula
3Na.H3O4P
InChI Key
RYFMWSXOAZQYPI-UHFFFAOYSA-K
Monoisotopic Mass
166.946203
Synonyms
Caswell No. 898EINECS 231-509-8Emulsiphos 440/660EPA Pesticide Chemical Code 076406NSC 215202Nutrifos STPSodium orthophosphate, tertiarySodium orthophosphate, tribasicSodium phosphate, anhydrousUNII-SX01TZO3QZNa3PO4Trinatriumphosphat
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Causes severe skin burns and eye damage |
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. |
| Routes of Exposure | Serious local effects by all routes of exposure. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
39 records
Chelating agentpH regulating agentPigmentCleaning agentLubricating agentFlavouring and nutrientBiocideHumectantDrierEmulsifierProcessing aids not otherwise specifiedAnti-caking agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
39 records
| List | Keyword | Source |
|---|---|---|
| fracking; water | NY Department of Conservation | CPCat |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =4.07 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| =17.87 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| SX01TZO3QZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SX01TZO3QZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SX01TZO3QZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SX01TZO3QZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =145.7 | mg/kg bw/day | NOAEL | oral | Human | ToxValDB PPRTV (CPHEA) |
| 1500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 3419 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 4000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =1 | mg/kg bw/day | RfD | oral | Human | ToxValDB RSL |
| =4 | mg/kg bw/day | RfD | oral | Human | ToxValDB RSL |
| =49 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB PPRTV (CPHEA) |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Trisodium orthophosphate | 231-509-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
SODIUM PHOSPHATE, TRIBASIC
ChEMBL Phase
-1
Adverse Events
3
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
E339iii — ADI: 40 mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Trisodium phosphate?
Trisodium phosphate appears on 8 regulatory/inventory lists including fracking; water, Europe; plastic_additive, active_ingredient; Europe; Pesticides, and 5 more. Source: EPA CPDat.
Is Trisodium phosphate used in cosmetics?
Yes, Trisodium phosphate is also indexed as a cosmetic ingredient under the name Trisodium Phosphate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Trisodium phosphate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Does Trisodium phosphate have different safety status in cosmetics vs industrial chemicals?
Trisodium phosphate is classified GHS Danger (H315, H319, H335, H314, H318) in the chemicals database but is allowed in EU cosmetics.
Is Trisodium phosphate used outside industrial chemicals?
Trisodium phosphate also appears in cosmetics, pharmaceutical, food safety databases.