Danger GHS08 NOAEL Data IARC Group 2B SVHC Prop 65 REACH Registered Cosmetic Ingredient

Phenolphthalein

Also known as: 3,3-Bis(4-hydroxyphenyl)-2-benzofuran-1(3H)-one, 5-18-04-00188, BRN 0284423, Correctol, alpha-Di(p-hydroxyphenyl)phthalide (+15 more)

CAS 77-09-8

Phenolphthalein (CAS 77-09-8) is a chemical substance with GHS signal word Danger; key hazard signal: H350; H341; H361f ***. Key regulatory status: SVHC Candidate List, California Proposition 65, REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, IARC, ECHA REACH, ECHA SVHC, CA Prop 65, EPA TRI.

View cosmetic safety profile for Phenolphthalein →

SOURCE NOAEL studies
NOAEL studies
61
SOURCE Chemical inventory jurisdictions
Regulatory lists
7
SOURCE EU CLP Annex VI
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields
Name
Phenolphthalein
CAS Number
77-09-8
DTXSID
DTXSID0021125
Molecular Formula
C20H14O4
InChI Key
KJFMBFZCATUALV-UHFFFAOYSA-N
Monoisotopic Mass
318.089209
Synonyms
3,3-Bis(4-hydroxyphenyl)-2-benzofuran-1(3H)-one5-18-04-00188BRN 0284423Correctolalpha-Di(p-hydroxyphenyl)phthalideDihydroxyphthalophenoneEINECS 201-004-7EspotabsEvac-U-GenEvac-Q-KitEvac-Q-KwikEvac-V-Lax

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 2BPossibly carcinogenic199976

Substance of Very High Concern (SVHC)

Candidate List status and reason under the ECHA REACH SVHC program.

SOURCE ECHA 1 records
SubstanceReasonIncluded
PhenolphthaleinCarcinogenic (Article 57a)19-Dec-2011

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records
ChemicalToxicity TypeCancerDevelopmentalListed
-cancerYesNo-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Carc. 1B; Muta. 2; Repr. 2H350; H341; H361f ***GHS08Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records
No specific technical function

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 7 records
ListKeywordSource
banned; Europe; Personal careEuropean CommissionCosIng
active_ingredient; AustraliaAustralian Pesticides and Veterinary Medicines AuthorityCPCat
pharmaceuticalUS International Trade CommissionCPCat
OEHHA Proposition 65 (3/2019)STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCYOEHHA Proposition 65 List
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
OEHHA Proposition 65 (1/2023)California Office of Environmental Health Hazard AssessmentOEHHA Proposition 65 List

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 61 studies
ValueUnitEndpointRouteSpeciesSource
7.38945042561721uMAC50--NTP ICE endocrine
33.6958260508959uMAC50--NTP ICE endocrine
5.07312527582202uMACC--NTP ICE endocrine
32.4294634408271uMACC--NTP ICE endocrine
ABcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
ABcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
ABcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
ABcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
41.6uL/min/10^6 cellsClint-RatNTP ICE adme parameters
47.4uL/min/10^6 cellsClint-HumanNTP ICE adme parameters
6QK969R2IFUNIIFDA UNII substance identifier--openFDA substances
6QK969R2IFUNIIFDA UNII substance identifier--openFDA substances
6QK969R2IFUNIIFDA UNII substance identifier--openFDA substances
6QK969R2IFUNIIFDA UNII substance identifier--openFDA substances
0.0086fractionFu-RatNTP ICE adme parameters
0.03116fractionFu-HumanNTP ICE adme parameters
2BIARC groupIARC carcinogenicity classification--IARC Monographs
2unitlessIARC group--NTP ICE cancer
=1mg/dayLELinjectionRatToxValDB Uterotrophic Hershberger DB
=300mg/kg bw/dayLELoralMouseToxValDB ToxRefDB
=300mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=400mg/kg bw/dayLELoralMouseToxValDB ToxRefDB
=400mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=500mg/kg bw/dayLELoralMouseToxValDB ToxRefDB
=500mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=1700mg/kg bw/dayLELoralRatToxValDB ToxRefDB
=1700mg/kg bw/dayLELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=2400mg/kg bw/dayLELoralMouseToxValDB ToxRefDB
=2400mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=10500mg/kg bw/dayLELoralRatToxValDB ToxRefDB
=10500mg/kg bw/dayLELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=11000mg/kg bw/dayLELoralRatToxValDB ToxRefDB
=11000mg/kg bw/dayLELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=15000mg/kg bw/dayLELoralMouseToxValDB ToxRefDB
=15000mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=2000mg/kg bw/dayLOAELoralMouseToxValDB ToxRefDB
=2000mg/kg bw/dayLOAELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
-unitlessModel Score--NTP ICE endocrine
0.174unitlessModel Score--NTP ICE endocrine
0.276unitlessModel Score--NTP ICE endocrine
>-mg/kg bw/dayNELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=400mg/kg bw/dayNELoralRatToxValDB ToxRefDB
=400mg/kg bw/dayNELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=800mg/kg bw/dayNELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=1200mg/kg bw/dayNELoralMouseToxValDB ToxRefDB
=1200mg/kg bw/dayNELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=4000mg/kg bw/dayNELoralRatToxValDB ToxRefDB
=4000mg/kg bw/dayNELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=4500mg/kg bw/dayNELoralRatToxValDB ToxRefDB
=4500mg/kg bw/dayNELoralrat (fischer; Fischer 344)EPA ToxRefDB v3

Showing 50 of 61 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredPhenolphthalein201-004-7ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records
ChemicalCategoryFlags
Phenolphthalein--

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed PHENOLPHTHALEIN
ChEMBL Phase
4
Adverse Events
115
Bioactivity
9
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Phenolphthalein?

Phenolphthalein (CAS 77-09-8) is classified under EU CLP Annex VI as Carc. 1B; Muta. 2; Repr. 2 with signal word Danger. Hazard statements: H350; H341; H361f ***. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Phenolphthalein?

Phenolphthalein has 61 NOAEL studies in the database. The lowest reported value is 5.07312527582202 uM. Source: NTP ICE endocrine.

What regulatory lists include Phenolphthalein?

Phenolphthalein appears on 6 regulatory/inventory lists including banned; Europe; Personal care, active_ingredient; Australia, pharmaceutical, and 3 more. Source: EPA CPDat.

Is Phenolphthalein a carcinogen according to IARC?

Phenolphthalein is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 1999). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Phenolphthalein on the California Proposition 65 list?

Yes, Phenolphthalein is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.

Is Phenolphthalein a Substance of Very High Concern (SVHC)?

Yes, Phenolphthalein is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Carcinogenic (Article 57a). Source: ECHA SVHC Candidate List.

Is Phenolphthalein used in cosmetics?

Yes, Phenolphthalein is also indexed as a cosmetic ingredient under the name Phenolphthalein. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Phenolphthalein come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, ECHA SVHC Candidate List, California Proposition 65, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Phenolphthalein have different safety status in cosmetics vs industrial chemicals?

Phenolphthalein is prohibited in EU cosmetics but has active industrial GHS classifications (H350, H341, H361f).

Is Phenolphthalein used outside industrial chemicals?

Phenolphthalein also appears in cosmetics, pharmaceutical databases.