What is the NOAEL for 5,5-Dimethylhydantoin?
5,5-Dimethylhydantoin has 62 NOAEL studies in the database. The lowest reported value is 60 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
5,5-Dimethylhydantoin
Also known as: 2,4-Imidazolidinedione, 5,5-dimethyl-, Dantoin DMH, NSC 8652, Dantoin 736, 5,5-Dimethyl-2,4-imidazolidinedione (+12 more)
CAS 77-71-4
5,5-Dimethylhydantoin (CAS 77-71-4) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
62
SOURCE
Chemical inventory jurisdictions
Regulatory lists
2
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
22 fields
Name
5,5-Dimethylhydantoin
CAS Number
77-71-4
Molecular Formula
C5H8N2O2
InChI Key
YIROYDNZEPTFOL-UHFFFAOYSA-N
Monoisotopic Mass
128.058578
Synonyms
2,4-Imidazolidinedione, 5,5-dimethyl-Dantoin DMHNSC 8652Dantoin 7365,5-Dimethyl-2,4-imidazolidinedione5,5-Dimethyl-Imidazolidine-2,4-dione4,4-Dimethyl-2,5-dioxoimidazolidineDM HydantoinFennosurf 300Hydantoin, 5,5-dimethyl-EC No.: 201-051-35-24-05-00348
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
3 records
Surfactant (surface active agent)Viscosity modifierSoftener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 50 of 62 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =60 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 34032MQ9RO | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1 | mg/kg bw/day | LEL | oral | Rabbit | ToxValDB ToxRefDB |
| =1 | mg/kg bw/day | LEL | oral | rabbit (new zealand white; New Zealand White) | EPA ToxRefDB v3 |
| =100 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =100 | mg/kg bw/day | LEL | oral | rat (sprague dawley; CD(SD)BR) | EPA ToxRefDB v3 |
| =120 | mg/kg bw/day | LEL | oral | Dog | ToxValDB ToxRefDB |
| =120 | mg/kg bw/day | LEL | oral | dog (beagle; beagle) | EPA ToxRefDB v3 |
| =321.1 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =321.1 | mg/kg bw/day | LEL | oral | mouse (cd1; Crl:CD-1(ICR)BR) | EPA ToxRefDB v3 |
| >390 | mg/kg bw/day | LEL | dermal | rat | EPA ToxRefDB v3 |
| =414 | mg/kg bw/day | LEL | oral | Dog | ToxValDB ToxRefDB |
| =414 | mg/kg bw/day | LEL | oral | dog (beagle; beagle) | EPA ToxRefDB v3 |
| =500 | mg/kg bw/day | LEL | oral | Rabbit | ToxValDB ToxRefDB |
| >1000 | mg/kg bw/day | LEL | oral | Dog | ToxValDB ToxRefDB |
| >1000 | mg/kg bw/day | LEL | oral | dog (beagle) | EPA ToxRefDB v3 |
| >1009 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| >1009 | mg/kg bw/day | LEL | oral | mouse (cd1; Crl:CD-1(ICR)BR) | EPA ToxRefDB v3 |
| =1019 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =1019 | mg/kg bw/day | LEL | oral | rat (sprague dawley; Sprague Dawley) | EPA ToxRefDB v3 |
| =1050 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =1050 | mg/kg bw/day | LEL | oral | rat (sprague-dawley; Sprague-Dawley) | EPA ToxRefDB v3 |
| =1506 | mg/kg bw/day | LOAEL | oral | Dog | ToxValDB ToxRefDB |
| =1506 | mg/kg bw/day | LOAEL | oral | dog (beagle; beagle) | EPA ToxRefDB v3 |
| =5000 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB HPVIS |
| =9850 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB HPVIS |
| 500 | mg/kg bw/day | LOEL | Oral | Rabbit | NTP ICE dart |
| 1000 | mg/kg bw/day | LOEL | Oral | Rabbit | NTP ICE dart |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| >0 | mg/kg bw/day | NEL | oral | rabbit (new zealand white; New Zealand White) | EPA ToxRefDB v3 |
| =100 | mg/kg bw/day | NEL | oral | Rat | ToxValDB ToxRefDB |
| =100 | mg/kg bw/day | NEL | oral | rat (sprague-dawley; Sprague-Dawley) | EPA ToxRefDB v3 |
| =100.6 | mg/kg bw/day | NEL | oral | Mouse | ToxValDB ToxRefDB |
| =100.6 | mg/kg bw/day | NEL | oral | mouse (cd1; Crl:CD-1(ICR)BR) | EPA ToxRefDB v3 |
| =121 | mg/kg bw/day | NEL | oral | Dog | ToxValDB ToxRefDB |
| =121 | mg/kg bw/day | NEL | oral | dog (beagle; beagle) | EPA ToxRefDB v3 |
| =300 | mg/kg bw/day | NEL | oral | Rat | ToxValDB ToxRefDB |
| =300 | mg/kg bw/day | NEL | oral | rat | EPA ToxRefDB v3 |
| =303 | mg/kg bw/day | NEL | oral | Rat | ToxValDB ToxRefDB |
| =303 | mg/kg bw/day | NEL | oral | rat (sprague dawley; Sprague Dawley) | EPA ToxRefDB v3 |
| =320 | mg/kg bw/day | NEL | oral | Rat | ToxValDB ToxRefDB |
| =320 | mg/kg bw/day | NEL | oral | rat (sprague dawley; CD(SD)BR) | EPA ToxRefDB v3 |
| =500 | mg/kg bw/day | NEL | oral | rabbit (new zealand white; New Zealand White) | EPA ToxRefDB v3 |
| =23.4 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =100 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB HPVIS |
| =250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB HPVIS |
| =300 | mg/kg bw/day | NOAEL | oral | Dog | ECHA |
| =342 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB ToxRefDB |
| =342 | mg/kg bw/day | NOAEL | oral | dog (beagle; beagle) | EPA ToxRefDB v3 |
| =500 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB HPVIS |
Showing 50 of 62 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 5,5-dimethylhydantoin | 201-051-3 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Hair Care
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL3181806
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include 5,5-Dimethylhydantoin?
5,5-Dimethylhydantoin appears on 2 regulatory/inventory lists including Arts and crafts/Office supplies - home office - pens and markers; detected; Europe, inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.
Is 5,5-Dimethylhydantoin used in cosmetics?
Yes, 5,5-Dimethylhydantoin is also indexed as a cosmetic ingredient under the name DM HYDANTOIN. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 5,5-Dimethylhydantoin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 5,5-Dimethylhydantoin used outside industrial chemicals?
5,5-Dimethylhydantoin also appears in cosmetics, pharmaceutical databases.