NOAEL Data REACH Registered Cosmetic Ingredient

5,5-Dimethylhydantoin

Also known as: 2,4-Imidazolidinedione, 5,5-dimethyl-, Dantoin DMH, NSC 8652, Dantoin 736, 5,5-Dimethyl-2,4-imidazolidinedione (+12 more)

CAS 77-71-4

5,5-Dimethylhydantoin (CAS 77-71-4) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.

View cosmetic safety profile for DM HYDANTOIN →

SOURCE noael studies public
NOAEL studies
66
SOURCE chemical inventory jurisdictions
Regulatory lists
2
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 23 fields
Name
5,5-Dimethylhydantoin
CAS Number
77-71-4
DTXSID
DTXSID5021754
Molecular Formula
C5H8N2O2
InChI Key
YIROYDNZEPTFOL-UHFFFAOYSA-N
Monoisotopic Mass
128.058578
Synonyms
2,4-Imidazolidinedione, 5,5-dimethyl-Dantoin DMHNSC 8652Dantoin 7365,5-Dimethyl-2,4-imidazolidinedione5,5-Dimethyl-Imidazolidine-2,4-dione4,4-Dimethyl-2,5-dioxoimidazolidineDM HydantoinFennosurf 300Hydantoin, 5,5-dimethyl-EC No.: 201-051-35-24-05-00348

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records
Surfactant (surface active agent)Viscosity modifierSoftener and conditioner

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records
ListKeywordSource
Arts and crafts/Office supplies - home office - pens and markers; detected; EuropeDanish Environmental Protection AgencyDanish EPA
inert_ingredient; non_food_use; PesticidesEPACPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 66 studies
ValueUnitEndpointRouteSpeciesSource
=60mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
34032MQ9ROUNIIFDA UNII substance identifier--openFDA substances
34032MQ9ROUNIIFDA UNII substance identifier--openFDA substances
34032MQ9ROUNIIFDA UNII substance identifier--openFDA substances
34032MQ9ROUNIIFDA UNII substance identifier--openFDA substances
=1mg/kg bw/dayLELoralRabbitToxValDB_ToxRefDB
=1mg/kg bw/dayLELoralrabbit (new zealand white; New Zealand White)ToxRefDB_ToxRefDB_v3_pod.csv
=100mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=100mg/kg bw/dayLELoralrat (sprague dawley; CD(SD)BR)ToxRefDB_ToxRefDB_v3_pod.csv
=120mg/kg bw/dayLELoralDogToxValDB_ToxRefDB
=120mg/kg bw/dayLELoraldog (beagle; beagle)ToxRefDB_ToxRefDB_v3_pod.csv
=321.1mg/kg bw/dayLELoralMouseToxValDB_ToxRefDB
=321.1mg/kg bw/dayLELoralmouse (cd1; Crl:CD-1(ICR)BR)ToxRefDB_ToxRefDB_v3_pod.csv
>390mg/kg bw/dayLELdermalratToxRefDB_ToxRefDB_v3_pod.csv
=414mg/kg bw/dayLELoralDogToxValDB_ToxRefDB
=414mg/kg bw/dayLELoraldog (beagle; beagle)ToxRefDB_ToxRefDB_v3_pod.csv
=500mg/kg bw/dayLELoralRabbitToxValDB_ToxRefDB
>1000mg/kg bw/dayLELoralDogToxValDB_ToxRefDB
>1000mg/kg bw/dayLELoraldog (beagle)ToxRefDB_ToxRefDB_v3_pod.csv
>1008.5mg/kg bw/dayLELoralMouseToxValDB_ToxRefDB
>1008.5mg/kg bw/dayLELoralmouse (cd1; Crl:CD-1(ICR)BR)ToxRefDB_ToxRefDB_v3_pod.csv
=1019mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=1019mg/kg bw/dayLELoralrat (sprague dawley; Sprague Dawley)ToxRefDB_ToxRefDB_v3_pod.csv
=1050mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=1050mg/kg bw/dayLELoralrat (sprague-dawley; Sprague-Dawley)ToxRefDB_ToxRefDB_v3_pod.csv
=1506mg/kg bw/dayLOAELoralDogToxValDB_ToxRefDB
=1506mg/kg bw/dayLOAELoraldog (beagle; beagle)ToxRefDB_ToxRefDB_v3_pod.csv
=5000mg/kg bw/dayLOAELoralRatToxValDB_HPVIS
=9850mg/kg bw/dayLOAELoralMouseToxValDB_HPVIS
500mg/kg bw/dayLOELOralRabbitNTP_ICE_dart
1000mg/kg bw/dayLOELOralRabbitNTP_ICE_dart
1000mg/kg bw/dayLOELOralRabbitNTP_ICE_dart
-unitlessModel Score--NTP_ICE_endocrine
>-mg/kg bw/dayNELoralrabbit (new zealand white; New Zealand White)ToxRefDB_ToxRefDB_v3_pod.csv
=100mg/kg bw/dayNELoralRatToxValDB_ToxRefDB
=100mg/kg bw/dayNELoralrat (sprague-dawley; Sprague-Dawley)ToxRefDB_ToxRefDB_v3_pod.csv
=100.6mg/kg bw/dayNELoralMouseToxValDB_ToxRefDB
=100.6mg/kg bw/dayNELoralmouse (cd1; Crl:CD-1(ICR)BR)ToxRefDB_ToxRefDB_v3_pod.csv
=121mg/kg bw/dayNELoralDogToxValDB_ToxRefDB
=121mg/kg bw/dayNELoraldog (beagle; beagle)ToxRefDB_ToxRefDB_v3_pod.csv
=300mg/kg bw/dayNELoralRatToxValDB_ToxRefDB
=300mg/kg bw/dayNELoralratToxRefDB_ToxRefDB_v3_pod.csv
=303mg/kg bw/dayNELoralRatToxValDB_ToxRefDB
=303mg/kg bw/dayNELoralrat (sprague dawley; Sprague Dawley)ToxRefDB_ToxRefDB_v3_pod.csv
=320mg/kg bw/dayNELoralRatToxValDB_ToxRefDB
=320mg/kg bw/dayNELoralrat (sprague dawley; CD(SD)BR)ToxRefDB_ToxRefDB_v3_pod.csv
=500mg/kg bw/dayNELoralrabbit (new zealand white; New Zealand White)ToxRefDB_ToxRefDB_v3_pod.csv
=23.4mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=100mg/kg bw/dayNOAELoralRabbitToxValDB_HPVIS
=250mg/kg bw/dayNOAELoralRatToxValDB_HPVIS

Showing 50 of 66 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered5,5-dimethylhydantoin201-051-3ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Hair Care
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3181806
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 5,5-Dimethylhydantoin?

5,5-Dimethylhydantoin has 66 NOAEL studies in the database. The lowest reported value is 0 mg/kg bw/day via oral in rabbit (new zealand white; New Zealand White). Source: ToxRefDB_ToxRefDB_v3_pod.csv.

What regulatory lists include 5,5-Dimethylhydantoin?

5,5-Dimethylhydantoin appears on 2 regulatory/inventory lists including Arts and crafts/Office supplies - home office - pens and markers; detected; Europe, inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.

Is 5,5-Dimethylhydantoin used in cosmetics?

Yes, 5,5-Dimethylhydantoin is also indexed as a cosmetic ingredient under the name DM HYDANTOIN. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 5,5-Dimethylhydantoin come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 5,5-Dimethylhydantoin used outside industrial chemicals?

5,5-Dimethylhydantoin also appears in cosmetics, pharmaceutical databases.