What is the NOAEL for Ethyl methylphenylglycidate?
Ethyl methylphenylglycidate has 28 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ethyl methylphenylglycidate
Also known as: Ethyl-3-methyl-3-phenylglycidate, 3-Methyl-3-phenylglycidic acid, ethyl ester, 2-Oxiranecarboxylic acid, 3-methyl-3-phenyl-, ethyl ester, C-16 aldehyde, 5-18-06-00385 (+14 more)
CAS 77-83-8
Ethyl methylphenylglycidate (CAS 77-83-8) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
View cosmetic safety profile for Ethyl Methylphenylglycidate →
SOURCE
noael studies public
NOAEL studies
28
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Ethyl methylphenylglycidate
CAS Number
77-83-8
DTXSID
DTXSID8020591
Molecular Formula
C12H14O3
InChI Key
LQKRYVGRPXFFAV-UHFFFAOYSA-N
Monoisotopic Mass
206.094294
Synonyms
Ethyl-3-methyl-3-phenylglycidate3-Methyl-3-phenylglycidic acid, ethyl ester2-Oxiranecarboxylic acid, 3-methyl-3-phenyl-, ethyl esterC-16 aldehyde5-18-06-00385BRN 0012299Butanoic acid, 2,3-epoxy-3-phenyl-, ethyl esterEINECS 201-061-8alpha,beta-Epoxy-beta-methylhydrocinnamic acid, ethyl ester2,3-Epoxy-3-phenylbutyric acid, ethyl esterEthyl alpha,beta-epoxy-beta-methylhydrocinnamateEthyl alpha,beta-epoxy-beta-methylphenylpropionate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceViscosity modifierFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 28 of 28 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 52.0268387177582 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 45.158493294312 | uM | ACC | - | - | NTP_ICE_endocrine |
| <=0.5 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| =44.08 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =17.63 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| UD51D5KR4A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UD51D5KR4A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UD51D5KR4A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UD51D5KR4A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 648 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =5470 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.00327 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0102 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| ~35 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =35 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =39 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 50 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| ~60 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~78 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 125 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 195 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 250 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >1000 | mg/kg bw/day | NOAEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| =7.8 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 28 of 28 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ethyl 2,3-epoxy-3-phenylbutyrate | 201-061-8 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Ethyl methylphenylglycidate?
Ethyl methylphenylglycidate appears on 4 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), IFRA Transparency, Europe, and 1 more. Source: EPA CPDat.
Is Ethyl methylphenylglycidate used in cosmetics?
Yes, Ethyl methylphenylglycidate is also indexed as a cosmetic ingredient under the name Ethyl Methylphenylglycidate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ethyl methylphenylglycidate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Ethyl methylphenylglycidate used outside industrial chemicals?
Ethyl methylphenylglycidate also appears in cosmetics, food safety, cannabis databases.