NOAEL Data REACH Registered Cosmetic Ingredient

Basic Red 51

Also known as: 1H-Imidazolium, 2-[2-[4-(dimethylamino)phenyl]diazenyl]-1,3-dimethyl-, chloride (1:1)

CAS 77061-58-6

Basic Red 51 (CAS 77061-58-6) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Basic Red 51 →

Cross-Vertical Regulatory Divergence

Basic Red 51 is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319, H400, H410).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 6 fields

Name

Basic Red 51

CAS Number

77061-58-6

Molecular Formula

C13H18N5.ClH

InChI Key

NZDXSXLYLMHYJA-UHFFFAOYSA-M

Monoisotopic Mass

280.132898

Synonyms

1H-Imidazolium, 2-[2-[4-(dimethylamino)phenyl]diazenyl]-1,3-dimethyl-, chloride (1:1)

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care; restricted	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 40 of 40 studies

Value	Unit	Endpoint	Route	Species	Source
A7A946JJ6I	UNII	FDA UNII substance identifier	-	-	openFDA substances
10	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
=0.005	mg/kg	NOAEL	oral	rat	SCCS Opinion
=0.006	mg/kg	NOAEL	oral	rat	SCCS Opinion
=10	mg/kg bw/day	NOAEL	-	-	SCCS Opinion
=10	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
=10	mg/kg/day	NOAEL	dermal	-	SCCNFP Opinion
=10	mg/kg bw/day	NOAEL	oral	-	SCCNFP Opinion
=12.25	mg/kg	NOAEL	dermal	rat	SCCS Opinion
=12.25	mg/kg	NOAEL	dermal	rat	SCCNFP Opinion
=12.25	mg/kg bw/day	NOAEL	oral	-	SCCNFP Opinion
=20	mg/kg bw/day	NOAEL	oral	mouse	SCCS Opinion
=20	mg/kg bw/day	NOAEL	-	human	SCCNFP Opinion
=50	mg/kg bw/d	NOAEL	-	-	SCCS Opinion
=50	mg/kg	NOAEL	dermal	-	SCCNFP Opinion
=180	mg/kg bw/day	NOAEL	oral	mouse	SCCS Opinion
=180	mg/kg bw/day	NOAEL	-	human	SCCNFP Opinion
=2000	mg/kg bw	NOAEL	oral	-	SCCS Opinion
=20	mg/kg bw/day	NOEL	oral	Rat	ECHA
=180	mg/kg bw/day	NOEL	oral	Rat	ECHA
20	mg/kg bw/day	developmental toxicity	-	human	Regulatory source
20	mg/kg bw/day	developmental toxicity	oral	mouse	Regulatory source
20	mg/kg bw/day	developmental toxicity	-	-	Regulatory source
180	mg/kg bw/day	developmental toxicity	-	human	Regulatory source
180	mg/kg bw/day	developmental toxicity	oral	mouse	Regulatory source
180	mg/kg bw/day	developmental toxicity	-	-	Regulatory source
10	mg/kg bw/day	genotoxicity	-	-	Regulatory source
50	mg/kg bw/d	genotoxicity	-	-	Regulatory source
=0.005	mg/kg	repeated dose toxicity	oral	rat	Regulatory source
=0.006	mg/kg	repeated dose toxicity	oral	rat	Regulatory source
10	mg/kg/day	repeated dose toxicity	dermal	-	Regulatory source
10	mg/kg bw/day	repeated dose toxicity	dermal	-	Regulatory source
10	mg/kg bw/day	repeated dose toxicity	oral	-	Regulatory source
=10	mg/kg bw	repeated dose toxicity	oral	rat	Regulatory source
10	mg/kg bw/day	repeated dose toxicity	oral	-	Regulatory source
12.25	mg/kg	repeated dose toxicity	dermal	rat	Regulatory source
12.25	mg/kg bw/day	repeated dose toxicity	oral	-	Regulatory source
12.25	mg/kg	repeated dose toxicity	dermal	rat	Regulatory source
20	mg/kg bw/day	repeated dose toxicity	oral	-	Regulatory source
20	mg/kg bw/day	repeated dose toxicity	oral	-	Regulatory source

Showing 40 of 40 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	2-[[4-(dimethylamino)phenyl]azo]-1,3-dimethyl-1H-imidazolium chloride	278-601-4	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1445/11	20 September 2011	safe	0.5%	sensitisation potential; tertiary amine
SCCS/1332/10	2011-03-22	Based on the data provided, the SCCS is of the opinion that the use of Basic Red 51 with a maximum on-head concentration of 1% in non-oxidative hair dye formulations does not pose a risk to the health of the consumer. For a final assessment of the use of Basic Red 51 with a maximum on-head concentration of 0.5% in oxidative hair dye formulations, data on the stability in an oxidative environment should be provided.	1% (non-oxidative); 0.5% (oxidative, pending data)	Non-oxidative use up to 1% considered safe; oxidative use up to 0.5% cannot yet be finally assessed - data on stability in an oxidative environment still required.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Frequently Asked Questions

What is the NOAEL for Basic Red 51?

Basic Red 51 has 40 NOAEL studies in the database. The lowest reported value is A7A946JJ6I UNII. Source: openFDA substances.

What regulatory lists include Basic Red 51?

Basic Red 51 appears on 3 regulatory/inventory lists including children; Europe; Personal care, Europe; Personal care - hair coloring, Europe; Personal care; restricted. Source: EPA CPDat.

Is Basic Red 51 used in cosmetics?

Yes, Basic Red 51 is also indexed as a cosmetic ingredient under the name Basic Red 51. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Basic Red 51 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does Basic Red 51 have different safety status in cosmetics vs industrial chemicals?

Basic Red 51 is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H319, H400, H410).

Is Basic Red 51 used outside industrial chemicals?

Basic Red 51 also appears in cosmetics databases.