Danger GHS03GHS07GHS05 NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

Hydrogen peroxide

Also known as: Hydrogen peroxide (H2O2), Albone 35CG, Albone 50CG, Albone 70CG, Caswell No. 486AAA (+15 more)

CAS 7722-84-1

Hydrogen peroxide (CAS 7722-84-1) is a chemical substance with GHS signal word Danger; key hazard signal: H271; H332; H302; H314. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, IARC, ECHA REACH, OSHA.

View cosmetic safety profile for Hydrogen Peroxide →

Cross-Vertical Regulatory Divergence

Hydrogen peroxide is classified GHS Danger (H271, H332, H302, H314) in the chemicals database but is restricted in EU cosmetics at max Hair products: max 12% (w/v) in rinse-off oxidative hair treatment; ≤3% in other cosmetic products; professional-only above 6%.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

Hydrogen peroxide

CAS Number

7722-84-1

Molecular Formula

H2O2

InChI Key

MHAJPDPJQMAIIY-UHFFFAOYSA-N

Monoisotopic Mass

34.005479

Synonyms

Hydrogen peroxide (H2O2)Albone 35CGAlbone 50CGAlbone 70CGCaswell No. 486AAAEINECS 231-765-0EPA Pesticide Chemical Code 000595InteroxKastoneLenseptPeroxanPeroxide

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 3	Not classifiable	1998	36, Sup 7, 71

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Ox. Liq. 1; Acute Tox. 4 ; Acute Tox. 4 ; Skin Corr. 1A	H271; H332; H302; H314	GHS03; GHS07; GHS05	Danger

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 8 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	1 ppm (1.4 mg/m³)	1	1.4	N
NIOSH	TWA	1 ppm (1.4 mg/m³)	1	1.4	N
ACGIH	TWA	1 ppm [1990]	1	-	N
CAL/OSHA	TWA	1 ppm (1.4 mg/m³)	1	1.4	N
NIOSH	IDLH	75 ppm	75	-	-
AIHA	ERPG-1	10 ppm	10	-	-
AIHA	ERPG-2	50 ppm	50	-	-
AIHA	ERPG-3	100 ppm	100	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

Bleaching agentCleaning agentBiocideBrightenerPharmaceuticalOxidizing agentDeodorizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 60 records

List	Keyword	Source
active_ingredient; agricultural; applied; Pesticides	Arizona Department of Environmental Quality	State of Arizona
active_ingredient; agricultural; applied; Pesticides	Arizona Department of Environmental Quality	State of Arizona
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
active_ingredient; Europe; Pesticides	European Commission	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
CEDI	FDA	United States Food and Drug Administration (FDA)
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat
active_ingredient; agricultural; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides	USDA	United States Department of Agriculture (USDA)
active_ingredient; agricultural; Pesticides	USDA	United States Department of Agriculture (USDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 61 studies

Value	Unit	Endpoint	Route	Species	Source
20	mg/kg bw/day	-	oral	rat	Regulatory source
30	mg/kg/day	-	oral	rat	Regulatory source
30	mg/kg/day	-	oral	rat	Regulatory source
56.2	mg/kg/day	-	oral	rat	Regulatory source
56.2	mg/kg/day	-	oral	rat	Regulatory source
86	mg/kg bw/day	-	-	rat	Regulatory source
100	ppm	-	oral	rat	Regulatory source
100	ppm	-	oral	rat	Regulatory source
100	mg/kg bw/d	-	-	-	Regulatory source
200	mg/kg bw/d	-	dermal	rabbit	Regulatory source
1000	mg/kg bw/d	-	oral	-	Regulatory source
1000	mg/kg bw/d	-	oral	rabbit	Regulatory source
=1.4	mg/m3	DNEL local	inhalation	Human	ToxValDB GESTIS DNEL
1	unitless	EPA Classification	Ocular	Rabbit	NTP ICE eye irritation
=3	Unitless	EPA classification	oral	Rat	NTP ICE acute oral
=3	Unitless	EPA classification	oral	Rat (Female)	NTP ICE acute oral
3	unitless	EPA classification	Dermal	Rabbit	NTP ICE skin irritation
4	unitless	EPA classification	Dermal	Rat	NTP ICE acute dermal
BBX060AN9V	UNII	FDA UNII substance identifier	-	-	openFDA substances
4	unitless	GHS Classification	Inhalation	-	NTP ICE acute inhalation
=4	Unitless	GHS classification	oral	Rat	NTP ICE acute oral
5	unitless	GHS classification	Dermal	Rat	NTP ICE acute dermal
=5	Unitless	GHS classification	oral	Rat (Female)	NTP ICE acute oral
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	unitless	IARC group	-	-	NTP ICE cancer
2	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
2.15	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
=3129	mg/kg bw	LD50	oral	Rat (Female)	NTP ICE acute oral
>5000	mg/kg	LD50	Dermal	Rat	NTP ICE acute dermal
=50	mg/kg bw/day	LEL	injection	Rat	ECHA
=170	mg/m3	LEL	inhalation	Rat	ECHA
=2000	mg/m3	LEL	inhalation	Rat	ECHA
=0.005	mg/kg bw/day	LOAEL	oral	Rat	ECHA
=9.738	mg/m3	LOAEL	inhalation	Dog	ECHA
=14.6	mg/m3	LOAEL	inhalation	Rat	ECHA
=30	mg/kg bw/day	LOAEL	oral	Rat	ECHA
300	ppm	LOAEL	oral	mouse	COSMOS DB
=3000	ppm	LOAEL	oral	Mouse	ECHA
=0.0294	mmol	LOEL	environmental	European Rabbit	ToxValDB ECOTOX
=0.0441	mmol	LOEL	environmental	European Rabbit	ToxValDB ECOTOX
=0.6	mM	LOEL	injection	Dog	ToxValDB ECOTOX
=100	mM	LOEL	oral	Rat	ToxValDB ECOTOX
=300	mg/L	LOEL	oral	Mouse	ToxValDB ECOTOX
=0.15	%	NOAEL	oral	mouse	SCCS Opinion
=2.9	mg/m3	NOAEL	inhalation	Rat	ECHA
=5	%	NOAEL	oral	mouse	SCCS Opinion
=9.85	mg/m3	NOAEL	inhalation	Rat	ECHA
=20	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
=30	mg/kg/day	NOAEL	oral	rat	SCCS Opinion
=30	mg/kg/day	NOAEL	oral	rat	SCCNFP Opinion

Showing 50 of 61 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Hydrogen peroxide	231-765-0	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/1129/07	18 December 2007		25% in nail varnish not safe; lower concentrations may be acceptable	Neurotoxicity; reproductive toxicity; CNS effects; volatile organic compound; CMR concerns at cosmetic use levels
SCCP/0844/04	15 March 2005	safe with restrictions	0.1% for general public; 0.1-6% by professionals only	Oxidising agent; oral mucosal irritation; >0.1% only via dental professionals; safety for general public at ≤0.1%

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Hair products: max 12% (w/v) in rinse-off oxidative hair treatment; ≤3% in other cosmetic products; professional-only above 6%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed HYDROGEN PEROXIDE

ChEMBL Phase

Adverse Events

452

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 2 records

ADI: NOT SPECIFIED mg/kg bw | FDA GRAS: Notice does not provide a basis for a GRAS determination

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Hydrogen peroxide?

Hydrogen peroxide (CAS 7722-84-1) is classified under EU CLP Annex VI as Ox. Liq. 1; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1A with signal word Danger. Hazard statements: H271; H332; H302; H314. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Hydrogen peroxide?

Hydrogen peroxide has 61 NOAEL studies in the database. The lowest reported value is 0.005 mg/kg bw/day via oral in Rat. Source: ECHA.

What regulatory lists include Hydrogen peroxide?

Hydrogen peroxide appears on 17 regulatory/inventory lists including active_ingredient; agricultural; applied; Pesticides, active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, and 14 more. Source: EPA CPDat.

Is Hydrogen peroxide a carcinogen according to IARC?

Hydrogen peroxide is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

What are the occupational exposure limits for Hydrogen peroxide?

Occupational exposure limits for Hydrogen peroxide are set by OSHA, NIOSH, ACGIH. 8 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Hydrogen peroxide used in cosmetics?

Yes, Hydrogen peroxide is also indexed as a cosmetic ingredient under the name Hydrogen Peroxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Hydrogen peroxide come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Hydrogen peroxide have different safety status in cosmetics vs industrial chemicals?

Is Hydrogen peroxide used outside industrial chemicals?

Hydrogen peroxide also appears in cosmetics, pharmaceutical, food safety, cannabis databases.