What is the NOAEL for (-)-alpha-Pinene?
(-)-alpha-Pinene has 6 NOAEL studies in the database. The lowest reported value is 6.03 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
(-)-alpha-Pinene
Also known as: (1S,5S)-2,6,6-Trimethylbicyclo[3.1.1]hept-2-ene, 2-Pinene, (1S,5S)-(-)-, (-)-2-Pinene, (1S)-(-)-a-Pinene, Bicyclo(3.1.1)hept-2-ene, 2,6,6-trimethyl-, (1S,5S)- (+14 more)
CAS 7785-26-4
(-)-alpha-Pinene (CAS 7785-26-4) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
(-)-alpha-Pinene is classified GHS Danger (H226, H302, H304, H315, H317, H400, H410, H373) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
(-)-alpha-Pinene
CAS Number
7785-26-4
DTXSID
DTXSID2029290
Molecular Formula
C10H16
InChI Key
GRWFGVWFFZKLTI-IUCAKERBSA-N
Monoisotopic Mass
136.125201
Synonyms
(1S,5S)-2,6,6-Trimethylbicyclo[3.1.1]hept-2-ene2-Pinene, (1S,5S)-(-)-(-)-2-Pinene(1S)-(-)-a-PineneBicyclo(3.1.1)hept-2-ene, 2,6,6-trimethyl-, (1S,5S)-1S,5S-(-)-alpha-Pinene(1S) 2,6,6-Trimethyl-Bicyclo(3.1.1)hept-2-ene(1S,5S) 2,6,6-Trimethyl-Bicyclo(3.1.1)hept-2-eneBicyclo[3.1.1]hept-2-ene, 2,6,6-trimethyl-, (1S,5S)-Bicyclo[3.1.1]hept-2-ene, 2,6,6-trimethyl-, (1S)-(-)-(1S)-α-Pinene(-)-α-Pinene
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =6.03 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| TZR3GM95PR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TZR3GM95PR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TZR3GM95PR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TZR3GM95PR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene | 232-077-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3109297
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include (-)-alpha-Pinene?
(-)-alpha-Pinene appears on 5 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, air; detected; emissions; Europe; Other direct contact consumer goods, Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe, and 2 more. Source: EPA CPDat.
Is (-)-alpha-Pinene used in cosmetics?
Yes, (-)-alpha-Pinene is also indexed as a cosmetic ingredient under the name L-Alpha-Pinene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (-)-alpha-Pinene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does (-)-alpha-Pinene have different safety status in cosmetics vs industrial chemicals?
(-)-alpha-Pinene is classified GHS Danger (H226, H302, H304, H315, H317, H400, H410, H373) in the chemicals database but is restricted in EU cosmetics.
Is (-)-alpha-Pinene used outside industrial chemicals?
(-)-alpha-Pinene also appears in cosmetics, pharmaceutical databases.