What is the NOAEL for 3,7-Dimethyl-3-octanol?
3,7-Dimethyl-3-octanol has 10 NOAEL studies in the database. The lowest reported value is 11.14 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
3,7-Dimethyl-3-octanol
Also known as: 2,6-Dimethyl-6-octanol, 3-Octanol, 3,7-dimethyl-, EINECS 201-133-9, EINECS 260-912-1, FEMA No. 3060 (+5 more)
CAS 78-69-3
3,7-Dimethyl-3-octanol (CAS 78-69-3) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
9
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
3,7-Dimethyl-3-octanol
CAS Number
78-69-3
DTXSID
DTXSID7029110
Molecular Formula
C10H22O
InChI Key
DLHQZZUEERVIGQ-UHFFFAOYSA-N
Monoisotopic Mass
158.167065
Synonyms
2,6-Dimethyl-6-octanol3-Octanol, 3,7-dimethyl-EINECS 201-133-9EINECS 260-912-1FEMA No. 3060Linalool tetrahydrideNSC 128151TetrahydrolinaloolUNII-UM4XS5M134Tetrahydromuguol
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =11.14 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| UM4XS5M134 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UM4XS5M134 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UM4XS5M134 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| UM4XS5M134 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3,7-dimethyloctan-3-ol | 201-133-9 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3183871
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 3,7-Dimethyl-3-octanol?
3,7-Dimethyl-3-octanol appears on 9 regulatory/inventory lists including detected; Europe; Vehicle - car interior, air; detected; emissions; Europe; Vehicle - car interior - auto air freshener, Europe, and 6 more. Source: EPA CPDat.
Is 3,7-Dimethyl-3-octanol used in cosmetics?
Yes, 3,7-Dimethyl-3-octanol is also indexed as a cosmetic ingredient under the name Tetrahydrolinalool. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3,7-Dimethyl-3-octanol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 3,7-Dimethyl-3-octanol used outside industrial chemicals?
3,7-Dimethyl-3-octanol also appears in cosmetics, pharmaceutical databases.