Also known as: Isopentane, EINECS 201-142-8, Ethyldimethylmethane, UNII-ZH67814I0O, (CH3)2CH-CH2-CH3 (+5 more)
CAS 78-78-4
2-Methylbutane (CAS 78-78-4) is a chemical substance with GHS signal word Danger; key hazard signal: H224; H304; H336; H411. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA.
2-Methylbutane is classified GHS Danger (H224, H304, H336, H411) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 1; Asp. Tox. 1; STOT SE 3; Aquatic Chronic 2 | H224; H304; H336; H411 | GHS02; GHS08; GHS07; GHS09 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Extremely flammable liquid and vapour May cause drowsiness or dizziness May be fatal if swallowed and enters airways Toxic to aquatic life |
| Short-term Effects | If swallowed the substance easily enters the airways and could result in aspiration pneumonitis. Inhalation of high concentrations of the vapour may cause depression of the central nervous system. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 1000 ppm (2950 mg/m³) | 1000 | 2950 | N |
| NIOSH | TWA | 120 ppm (350 mg/m³) | 120 | 350 | N |
| NIOSH | CEILING | 610 ppm (1800 mg/m³) [15 minutes] | 610 | 1800 | N |
| ACGIH | TWA | 1000 ppm [2013] | 1000 | - | N |
| CAL/OSHA | TWA | 600 ppm (1800 mg/m³) | 600 | 1800 | N |
| NIOSH | IDLH | 1500 ppm (as n-Pentane) | 1500 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =3000 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| ZH67814I0O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZH67814I0O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZH67814I0O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZH67814I0O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =41313.7 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| =20 | mg/m3 | NOAEC | inhalation | Rat | ECHA |
Showing 7 of 7 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-methylbutane | 201-142-8 | ECHA overview → |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
2-Methylbutane (CAS 78-78-4) is classified under EU CLP Annex VI as Flam. Liq. 1; Asp. Tox. 1; STOT SE 3; Aquatic Chronic 2 with signal word Danger. Hazard statements: H224; H304; H336; H411. Source: EU CLP Annex VI (ECHA).
2-Methylbutane has 7 NOAEL studies in the database. The lowest reported value is 3000 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
2-Methylbutane appears on 5 regulatory/inventory lists including air; detected; emissions; Europe; Other direct contact consumer goods, detected; Europe; Other direct contact consumer goods, Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; Europe, and 2 more. Source: EPA CPDat.
Occupational exposure limits for 2-Methylbutane are set by OSHA, NIOSH, ACGIH. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, 2-Methylbutane is also indexed as a cosmetic ingredient under the name Isopentane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
2-Methylbutane is classified GHS Danger (H224, H304, H336, H411) in the chemicals database but is allowed in EU cosmetics.
2-Methylbutane also appears in cosmetics, pharmaceutical databases.