What is the NOAEL for 2-Butanol?
2-Butanol has 22 NOAEL studies in the database. The lowest reported value is 24.24 mg/L via Inhalation. Source: NTP ICE acute inhalation.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Butanol
Also known as: 2-01-00-00400, BRN 0773649, Butyl alcohol, sec-, Caswell No. 119C, EINECS 201-158-5 (+14 more)
CAS 78-92-2
2-Butanol (CAS 78-92-2) is a chemical substance. Key regulatory status: REACH registered, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA, EPA TRI.
Cross-Vertical Regulatory Divergence
2-Butanol is classified GHS CMR hazard (H226, H319, H335, H336, H303, H361) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
22
SOURCE
Chemical inventory jurisdictions
Regulatory lists
11
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
2-Butanol
CAS Number
78-92-2
Molecular Formula
C4H10O
InChI Key
BTANRVKWQNVYAZ-UHFFFAOYSA-N
Monoisotopic Mass
74.073165
Synonyms
2-01-00-00400BRN 0773649Butyl alcohol, sec-Caswell No. 119CEINECS 201-158-5EINECS 240-029-8EPA Pesticide Chemical Code 0015021-Methyl propanolMethylethyl carbinolButanol secondaireUNII-0TUL3ENK62Alcool butylique secondaire
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Flammable liquid and vapour May be harmful if swallowed Causes eye irritation May cause respiratory irritation May cause drowsiness or dizziness May be harmful if swallowed and enters airways |
| Short-term Effects | The substance is irritating to the eyes and upper respiratory tract. Exposure far above the OEL could cause lowering of consciousness. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour and by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
5 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 150 ppm (450 mg/m³) | 150 | 450 | N |
| NIOSH | TWA | 100 ppm (305 mg/m³) | 100 | 305 | N |
| NIOSH | STEL | 150 ppm (455 mg/m³) | 150 | 455 | N |
| CAL/OSHA | TWA | 100 ppm (305 mg/m³) | 100 | 305 | N |
| NIOSH | IDLH | 2000 ppm | 2000 | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
SolventFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
11 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; emissions; Europe; nondetect; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
| Europe | European Commission | Fl@vis |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 22 of 22 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =657 | mg/kg bw/day | BMDL (05) | oral | Rat | ToxValDB PPRTV (CPHEA) |
| =600 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 0TUL3ENK62 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 24.24 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 48.5 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =2054 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =2193 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =2328 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =6480 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =4.851e+4 | mg/m3 | LEL | inhalation | Rat | ECHA |
| =5.154e+4 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| =1.061e+4 | mg/m3 | LOAEC | inhalation | Rat | ECHA |
| =2.000e+4 | mg/L | LOAEL | oral | Rat | ECHA |
| =1.061e+4 | mg/m3 | NOAEC | inhalation | Rat | ECHA |
| >480 | mg/kg bw/day | NOAEL | oral | Rabbit | ECHA |
| 1644 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1771 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =1.000e+4 | mg/L | NOAEL | oral | Rat | ECHA |
| =3093 | mg/m3 | NOAEL (HEC) | inhalation | Rat | ToxValDB PPRTV (CPHEA) |
| =1.516e+4 | mg/m3 | NOEC | inhalation | Rat | ECHA |
| =30 | mg/m3 | RfC (provisional) | inhalation | Human | ToxValDB PPRTV (CPHEA) |
| =2 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB PPRTV (CPHEA) |
Showing 22 of 22 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Butan-2-ol | 201-158-5 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| sec-Butyl alcohol (2-Butanol) | - | - |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Rheology Modifier
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
BUTANOL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include 2-Butanol?
2-Butanol appears on 9 regulatory/inventory lists including IFRA Transparency, air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe, consumer_product; detected; Europe, and 6 more. Source: EPA CPDat.
What are the occupational exposure limits for 2-Butanol?
Occupational exposure limits for 2-Butanol are set by OSHA, NIOSH, CAL/OSHA. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is 2-Butanol used in cosmetics?
Yes, 2-Butanol is also indexed as a cosmetic ingredient under the name Sec-Butyl Alcohol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Butanol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Butanol have different safety status in cosmetics vs industrial chemicals?
2-Butanol is classified GHS CMR hazard (H226, H319, H335, H336, H303, H361) in the chemicals database but is allowed in EU cosmetics.
Is 2-Butanol used outside industrial chemicals?
2-Butanol also appears in cosmetics, pharmaceutical databases.