NOAEL Data REACH Registered Cosmetic Ingredient

2-Butanol

Also known as: 2-01-00-00400, BRN 0773649, Butyl alcohol, sec-, Caswell No. 119C, EINECS 201-158-5 (+14 more)

CAS 78-92-2

2-Butanol (CAS 78-92-2) is a chemical substance. Key regulatory status: REACH registered, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Sec-Butyl Alcohol →

Cross-Vertical Regulatory Divergence

2-Butanol is classified GHS CMR hazard (H226, H319, H335, H336, H303, H361) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

2-Butanol

CAS Number

78-92-2

DTXSID

DTXSID9021762

Molecular Formula

C4H10O

InChI Key

BTANRVKWQNVYAZ-UHFFFAOYSA-N

Monoisotopic Mass

74.073165

Synonyms

2-01-00-00400BRN 0773649Butyl alcohol, sec-Caswell No. 119CEINECS 201-158-5EINECS 240-029-8EPA Pesticide Chemical Code 0015021-Methyl propanolMethylethyl carbinolButanol secondaireUNII-0TUL3ENK62Alcool butylique secondaire

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	WARNING
GHS Hazard Statements	Flammable liquid and vapour May be harmful if swallowed Causes eye irritation May cause respiratory irritation May cause drowsiness or dizziness May be harmful if swallowed and enters airways
Short-term Effects	The substance is irritating to the eyes and upper respiratory tract. Exposure far above the OEL could cause lowering of consciousness. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 5 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	150 ppm (450 mg/m³)	150	450	N
NIOSH	TWA	100 ppm (305 mg/m³)	100	305	N
NIOSH	STEL	150 ppm (455 mg/m³)	150	455	N
CAL/OSHA	TWA	100 ppm (305 mg/m³)	100	305	N
NIOSH	IDLH	2000 ppm	2000	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 8 records

SolventFlavouring and nutrientFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 11 records

List	Keyword	Source
IFRA Transparency	IFRA	IFRA
air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
consumer_product; detected; Europe	Danish Environmental Protection Agency	Danish EPA
air; emissions; Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
Canada; pharmaceutical	DrugBank	DrugBank
Canada; pharmaceutical	DrugBank	DrugBank
consumer_product	P&G	Proctor & Gamble
Europe	European Commission	Fl@vis
inert_ingredient; non_food_use; Pesticides	EPA	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 25 of 25 studies

Value	Unit	Endpoint	Route	Species	Source
=657	mg/kg bw/day	BMDL (05)	oral	Rat	ToxValDB_PPRTV_(CPHEA)
=600	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
0TUL3ENK62	UNII	FDA UNII substance identifier	-	-	openFDA substances
0TUL3ENK62	UNII	FDA UNII substance identifier	-	-	openFDA substances
0TUL3ENK62	UNII	FDA UNII substance identifier	-	-	openFDA substances
0TUL3ENK62	UNII	FDA UNII substance identifier	-	-	openFDA substances
24.2378	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
48.5	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=2054	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=2193	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=2328	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=6480	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=48506.1	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=51537.7	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=10610.7	mg/m3	LOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=20000	mg/L	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=10610.7	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
>480	mg/kg bw/day	NOAEL	oral	Rabbit	ToxValDB_ECHA_IUCLID
1644	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
1771	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=10000	mg/L	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=3093	mg/m3	NOAEL (HEC)	inhalation	Rat	ToxValDB_PPRTV_(CPHEA)
=15158.2	mg/m3	NOEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=30	mg/m3	RfC (provisional)	inhalation	Human	ToxValDB_PPRTV_(CPHEA)
=2	mg/kg bw/day	RfD (provisional)	oral	Human	ToxValDB_PPRTV_(CPHEA)

Showing 25 of 25 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Butan-2-ol	201-158-5	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
sec-Butyl alcohol (2-Butanol)	-	-

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL BUTANOL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 2-Butanol?

2-Butanol has 25 NOAEL studies in the database. The lowest reported value is 600 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 2-Butanol?

2-Butanol appears on 9 regulatory/inventory lists including IFRA Transparency, air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe, consumer_product; detected; Europe, and 6 more. Source: EPA CPDat.

What are the occupational exposure limits for 2-Butanol?

Occupational exposure limits for 2-Butanol are set by OSHA, NIOSH, CAL/OSHA. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 2-Butanol used in cosmetics?

Yes, 2-Butanol is also indexed as a cosmetic ingredient under the name Sec-Butyl Alcohol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Butanol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Butanol have different safety status in cosmetics vs industrial chemicals?

2-Butanol is classified GHS CMR hazard (H226, H319, H335, H336, H303, H361) in the chemicals database but is allowed in EU cosmetics.

Is 2-Butanol used outside industrial chemicals?

2-Butanol also appears in cosmetics, pharmaceutical databases.