Danger GHS05 NOAEL Data REACH Registered Cosmetic Ingredient

1-Amino-2-propanol

Also known as: Monoisopropanolamine, 4-04-00-01665, BRN 0605275, EINECS 201-162-7, UNII-UE40BY1BZW (+5 more)

CAS 78-96-6

1-Amino-2-propanol (CAS 78-96-6) is a chemical substance with GHS signal word Danger; key hazard signal: H314. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Isopropanolamine →

Cross-Vertical Regulatory Divergence

1-Amino-2-propanol is classified GHS Danger (H314) in the chemicals database but is restricted in EU cosmetics at max 0.5%.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 16 fields

Name

1-Amino-2-propanol

CAS Number

78-96-6

DTXSID

DTXSID9021764

Molecular Formula

C3H9NO

InChI Key

HXKKHQJGJAFBHI-UHFFFAOYSA-N

Monoisotopic Mass

75.068414

Synonyms

Monoisopropanolamine4-04-00-01665BRN 0605275EINECS 201-162-7UNII-UE40BY1BZW1-Amino-2-HydroxypropanamineAminopropanolMipaMono-iso-propanolaminealpha-aminoisopropyl alcohol

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Skin Corr. 1B	H314	GHS05	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Combustible liquid Harmful if swallowed or in contact with skin Causes severe skin burns and eye damage Causes damage to respiratory tract May be harmful if swallowed and enters airways Harmful to aquatic life
Short-term Effects	The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. Medical observation is indicated. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.
Long-term Effects	Repeated or prolonged contact with skin may cause dermatitis.
Routes of Exposure	Serious local effects by all routes of exposure.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 35 records

pH regulating agentSolventCleaning agentEmulsifierBiocideFlavouring and nutrientChelating agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records

List	Keyword	Source
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
CEDI	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 6 of 6 studies

Value	Unit	Endpoint	Route	Species	Source
=3.6	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
UE40BY1BZW	UNII	FDA UNII substance identifier	-	-	openFDA substances
UE40BY1BZW	UNII	FDA UNII substance identifier	-	-	openFDA substances
UE40BY1BZW	UNII	FDA UNII substance identifier	-	-	openFDA substances
UE40BY1BZW	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	unitless	Model Score	-	-	NTP_ICE_endocrine

Showing 6 of 6 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	1-aminopropan-2-ol	201-162-7	ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

0.5%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL326602

ChEMBL Phase

Not listed

Adverse Events

869

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 1-Amino-2-propanol?

1-Amino-2-propanol (CAS 78-96-6) is classified under EU CLP Annex VI as Skin Corr. 1B with signal word Danger. Hazard statements: H314. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1-Amino-2-propanol?

1-Amino-2-propanol has 6 NOAEL studies in the database. The lowest reported value is 3.6 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 1-Amino-2-propanol?

1-Amino-2-propanol appears on 3 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), inert_ingredient; non_food_use; Pesticides, CEDI. Source: EPA CPDat.

Is 1-Amino-2-propanol used in cosmetics?

Yes, 1-Amino-2-propanol is also indexed as a cosmetic ingredient under the name Isopropanolamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1-Amino-2-propanol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 1-Amino-2-propanol have different safety status in cosmetics vs industrial chemicals?

1-Amino-2-propanol is classified GHS Danger (H314) in the chemicals database but is restricted in EU cosmetics at max 0.5%.

Is 1-Amino-2-propanol used outside industrial chemicals?

1-Amino-2-propanol also appears in cosmetics, pharmaceutical databases.