What is the GHS hazard classification for N-Methylacetamide?
N-Methylacetamide (CAS 79-16-3) is classified under EU CLP Annex VI as Repr. 1B with signal word Danger. Hazard statements: H360D ***. Source: EU CLP Annex VI (ECHA).
Danger
GHS08
NOAEL Data
SVHC
REACH Registered
Cosmetic Ingredient
N-Methylacetamide
Also known as: Acetamide, methyl-, Acetic acid, amide, N-methyl, EINECS 201-182-6, N-Monomethylacetamide, UNII-V0T777481M (+2 more)
CAS 79-16-3
N-Methylacetamide (CAS 79-16-3) is a chemical substance with GHS signal word Danger; key hazard signal: H360D ***. Key regulatory status: SVHC Candidate List, REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ECHA SVHC.
Cross-Vertical Regulatory Divergence
N-Methylacetamide is prohibited in EU cosmetics but has active industrial GHS classifications (H360D).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
N-Methylacetamide
CAS Number
79-16-3
DTXSID
DTXSID0047167
Molecular Formula
C3H7NO
InChI Key
OHLUUHNLEMFGTQ-UHFFFAOYSA-N
Monoisotopic Mass
73.052764
Synonyms
Acetamide, methyl-Acetic acid, amide, N-methylEINECS 201-182-6N-MonomethylacetamideUNII-V0T777481MAcetylmethylamineN-Acetyl-N-methylamine
Substance of Very High Concern (SVHC)
Candidate List status and reason under the ECHA REACH SVHC program.
SOURCE
ECHA (EU)
1 records
| Substance | Reason | Included |
|---|---|---|
| N-methylacetamide | Toxic for reproduction (Article 57c) | 19-Dec-2012 |
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Repr. 1B | H360D *** | GHS08 | Danger |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
No specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| V0T777481M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| V0T777481M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| V0T777481M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| V0T777481M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | N-methylacetamide | 201-182-6 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Hair Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL11544
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What is the NOAEL for N-Methylacetamide?
N-Methylacetamide has 5 NOAEL studies in the database. The lowest reported value is V0T777481M UNII. Source: openFDA substances.
What regulatory lists include N-Methylacetamide?
N-Methylacetamide appears on 1 regulatory/inventory list including banned; Europe; Personal care. Source: EPA CPDat.
Is N-Methylacetamide a Substance of Very High Concern (SVHC)?
Yes, N-Methylacetamide is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Toxic for reproduction (Article 57c). Source: ECHA SVHC Candidate List.
Is N-Methylacetamide used in cosmetics?
Yes, N-Methylacetamide is also indexed as a cosmetic ingredient under the name Methyl Acetamide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for N-Methylacetamide come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does N-Methylacetamide have different safety status in cosmetics vs industrial chemicals?
N-Methylacetamide is prohibited in EU cosmetics but has active industrial GHS classifications (H360D).
Is N-Methylacetamide used outside industrial chemicals?
N-Methylacetamide also appears in cosmetics, pharmaceutical databases.