What is the NOAEL for 4,4'-Propane-2,2-diyldicyclohexanol?
4,4'-Propane-2,2-diyldicyclohexanol has 9 NOAEL studies in the database. The lowest reported value is 4.93 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4,4'-Propane-2,2-diyldicyclohexanol
Also known as: Cyclohexanol, 4,4'-(1-methylethylidene)bis-, 2,2-Bis(4-hydroxycyclohexyl)propane, Dodecahydrobisphenol A, EINECS 201-244-2, 1,1'-Isopropylidenebis(4-cyclohexanol) (+2 more)
CAS 80-04-6
4,4'-Propane-2,2-diyldicyclohexanol (CAS 80-04-6) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
4,4'-Propane-2,2-diyldicyclohexanol is prohibited in EU cosmetics but has active industrial GHS classifications (H319, H412).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
4,4'-Propane-2,2-diyldicyclohexanol
CAS Number
80-04-6
DTXSID
DTXSID0044993
Molecular Formula
C15H28O2
InChI Key
CDBAMNGURPMUTG-UHFFFAOYSA-N
Monoisotopic Mass
240.20893
Synonyms
Cyclohexanol, 4,4'-(1-methylethylidene)bis-2,2-Bis(4-hydroxycyclohexyl)propaneDodecahydrobisphenol AEINECS 201-244-21,1'-Isopropylidenebis(4-cyclohexanol)NSC 8990UNII-NXZ4H12R1Z
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
No specific technical function
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =4.93 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| NXZ4H12R1Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| NXZ4H12R1Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| NXZ4H12R1Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| NXZ4H12R1Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| ~100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =20 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4,4'-isopropylidenedicyclohexanol | 201-244-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3185065
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
Is 4,4'-Propane-2,2-diyldicyclohexanol used in cosmetics?
Yes, 4,4'-Propane-2,2-diyldicyclohexanol is also indexed as a cosmetic ingredient under the name Hydrogenated Bisphenol A. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4,4'-Propane-2,2-diyldicyclohexanol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 4,4'-Propane-2,2-diyldicyclohexanol have different safety status in cosmetics vs industrial chemicals?
4,4'-Propane-2,2-diyldicyclohexanol is prohibited in EU cosmetics but has active industrial GHS classifications (H319, H412).
Is 4,4'-Propane-2,2-diyldicyclohexanol used outside industrial chemicals?
4,4'-Propane-2,2-diyldicyclohexanol also appears in cosmetics, pharmaceutical databases.