What is the NOAEL for Benzalkonium chloride?
Benzalkonium chloride has 32 NOAEL studies in the database. The lowest reported value is 0 % via Dermal. Source: NTP ICE skin sensitization.
NOAEL Data
Cosmetic Ingredient
Benzalkonium chloride
Also known as: ADBAC (C12 50%, C14 30%, C16 17%, C18 3%), BTC 2565, BTC 471, Quatramine 50, EC No.: 616-786-9 (+15 more)
CAS 8001-54-5
Benzalkonium chloride (CAS 8001-54-5) is a chemical substance. Key regulatory status: 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
NOAEL studies
NOAEL studies
32
SOURCE
Chemical inventory jurisdictions
Regulatory lists
8
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
Benzalkonium chloride
CAS Number
8001-54-5
Synonyms
ADBAC (C12 50%, C14 30%, C16 17%, C18 3%)BTC 2565BTC 471Quatramine 50EC No.: 616-786-9ADBACAlkyl* dimethyl benzyl ammonium chloride *(50%C12, 30%C14, 17%C16, 3%C18)Alkyl dimethylbenzyl ammonium chlorideAlkyldimethyl(phenylmethyl)quaternary ammonium chloridesAmmonyxArquad B 100Arquad dmmcb-75
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Surfactant (surface active agent)BiocidePreservativePharmaceuticalAnti-static agentDeodorizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe | Danish EPA | Danish EPA |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 32 of 32 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 12.28 | uM | AC50 | - | - | NTP ICE endocrine |
| 5.825 | uM | ACC | - | - | NTP ICE endocrine |
| 10.37 | uM | ACC | - | - | NTP ICE endocrine |
| 240 | min | Breakthrough Time | Dermal | - | NTP ICE skin irritation |
| <0.1 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 0.261 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 1.01 | ug/mL | CV70 | Dermal | - | NTP ICE skin sensitization |
| 3 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 2.8 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 0 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 1.4 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 108 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP ICE eye irritation |
| >2000 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 0.1 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 1 | unitless | EPA Classification | Ocular | Rabbit | NTP ICE eye irritation |
| 5R9MGR4CR5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| F5UM2KM3W7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| 4.03 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| 1.45 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 1.5 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 1 | %/sec | Intensity | Ocular | - | NTP ICE eye irritation |
| =2 | % | LOEL | dermal | Mouse | ToxValDB ECOTOX |
| =10 | % w/v | LOEL | environmental | European Rabbit | ToxValDB ECOTOX |
| 0 | s | Lag time | Ocular | - | NTP ICE eye irritation |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.0727 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.251 | unitless | Model Score | - | - | NTP ICE endocrine |
| =1 | % | NOEL | dermal | Mouse | ToxValDB ECOTOX |
| =5 | % | NOEL | dermal | Mouse | ToxValDB ECOTOX |
| =0.44 | mg/kg bw/day | PAD (RfD) | oral | Human | ToxValDB EPA OPP |
| 90 | % | Plateau level | Ocular | - | NTP ICE eye irritation |
Showing 32 of 32 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
0.1%
Category
preservative
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
FDA GRAS: At the notifier's request, FDA ceased to evaluate this notice
View full food safety profile →Frequently Asked Questions
What regulatory lists include Benzalkonium chloride?
Benzalkonium chloride appears on 7 regulatory/inventory lists including active_ingredient; Europe; Pesticides, Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe, pharmaceutical, and 4 more. Source: EPA CPDat.
Is Benzalkonium chloride used in cosmetics?
Yes, Benzalkonium chloride is also indexed as a cosmetic ingredient under the name Benzalkonium Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Benzalkonium chloride come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Benzalkonium chloride used outside industrial chemicals?
Benzalkonium chloride also appears in cosmetics, food safety databases.