What is the NOAEL for D & C Yellow 11?
D & C Yellow 11 has 11 NOAEL studies in the database. The lowest reported value is 1.045 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
D & C Yellow 11
Also known as: C.I. Solvent Yellow 33, Yellow 11, D.C. Yellow Dye No. 11, Chinoline Yellow D sol. in spirits, EINECS 232-318-2 (+3 more)
CAS 8003-22-3
D & C Yellow 11 (CAS 8003-22-3) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
D & C Yellow 11 is classified GHS CMR hazard (H315, H317, H319, H335, H351) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
D & C Yellow 11
CAS Number
8003-22-3
DTXSID
DTXSID7024906
Synonyms
C.I. Solvent Yellow 33Yellow 11D.C. Yellow Dye No. 11Chinoline Yellow D sol. in spiritsEINECS 232-318-22-(2-Quinolinyl)-1H-indene-1,3(2H)-dioneSolvant Yellow 33UNII-44F3HYL954
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
DyeFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.045 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 44F3HYL954 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 44F3HYL954 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 44F3HYL954 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 44F3HYL954 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| <37 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
| <48 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_HESS |
| 1700 | ppm | POLY-3 lowest dose | Dosed feed | Rat | NTP_ICE_cancer |
| 5000 | ppm | POLY-3 lowest dose | Dosed feed | Rat | NTP_ICE_cancer |
| 0.5 | % | Top dose | Dosed feed | Rat | NTP_ICE_cancer |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,3-isobenzofurandione, reaction products with methylquinoline and quinoline | 232-318-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Colorants
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1486465
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
D&C Yellow 10 — 1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include D & C Yellow 11?
D & C Yellow 11 appears on 6 regulatory/inventory lists including banned; Europe; Personal care, IFRA Transparency, consumer_product, and 3 more. Source: EPA CPDat.
Is D & C Yellow 11 used in cosmetics?
Yes, D & C Yellow 11 is also indexed as a cosmetic ingredient under the name CI 47000. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for D & C Yellow 11 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Does D & C Yellow 11 have different safety status in cosmetics vs industrial chemicals?
D & C Yellow 11 is classified GHS CMR hazard (H315, H317, H319, H335, H351) in the chemicals database but is allowed in EU cosmetics.
Is D & C Yellow 11 used outside industrial chemicals?
D & C Yellow 11 also appears in cosmetics, pharmaceutical, food safety databases.