NOAEL Data Cosmetic Ingredient

C.I. Acid Yellow 3 disodium salt

Also known as: C.I. Acid Yellow 4, C.I. Acid Yellow 3, D & C Yellow No. 10, Food Yellow 13, Japan Yellow 203 (+12 more)

CAS 8004-92-0

C.I. Acid Yellow 3 disodium salt (CAS 8004-92-0) is a chemical substance. Key regulatory status: 17 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.

View cosmetic safety profile for D&C Yellow No. 10 (Quinoline Yellow) →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 19 fields

Name

C.I. Acid Yellow 3 disodium salt

CAS Number

8004-92-0

Synonyms

C.I. Acid Yellow 4C.I. Acid Yellow 3D & C Yellow No. 10Food Yellow 13Japan Yellow 203Quinoline Yellow Extra2-(2-Quinolyl)-1,3-indandione disulfonic acid disodium saltSchultz No. 918ChinogelbChinogelb ExtraChinogelb wasserloeslichJaune de quinoleine

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

DyeFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 17 records

List	Keyword	Source
Arts and crafts/Office supplies - body paint - tattoo ink; Europe	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - body hygiene - body wash	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - hair styling and care - shampoo	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe	Danish EPA	Danish EPA
Cleaning products and household care; Europe	Danish EPA	Danish EPA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
Personal care	FDA	United States Food and Drug Administration (FDA)
Medical/dental	FDA	United States Food and Drug Administration (FDA)
Arts and crafts/Office supplies - body paint - tattoo ink; Europe	Danish Environmental Protection Agency	Danish EPA
Canada; pharmaceutical	DrugBank	DrugBank
IFRA Transparency	IFRA	IFRA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 31 of 31 studies

Value	Unit	Endpoint	Route	Species	Source
3	%	-	-	-	Regulatory source
4	-	-	-	-	Regulatory source
>50	-	-	-	rat	Regulatory source
=0.5	mg/kg bw/day	ADI	-	Consumers	EFSA
<=3	mg/kg	ADI	oral	Human	WHO/JECFA
35SW5USQ3G	UNII	FDA UNII substance identifier	-	-	openFDA substances
0	unitless	Model Score	-	-	NTP ICE endocrine
=0.0783	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
=3	%	NOAEL	-	-	SCCS Opinion
=4	-	NOAEL	-	-	SCCS Opinion
=50	mg/kg bw/day	NOAEL	oral	Rat	EFSA
=50	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
>50	-	NOAEL	-	rat	SCCS Opinion
=50	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA
=100	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
=250	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
=1000	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
=1500	-	NOAEL	oral	rat	SCCS Opinion
=2500	-	NOAEL	-	rat	SCCS Opinion
50	mg/kg bw/day	repeated dose toxicity	oral	rat	Regulatory source
100	mg/kg bw	repeated dose toxicity	oral	rat	Regulatory source
1000	mg/kg bw/day	repeated dose toxicity	oral	rat	Regulatory source
1500	-	repeated dose toxicity	oral	rat	Regulatory source
2500	-	repeated dose toxicity	-	rat	Regulatory source
=0.0783	mg/kg bw	reproductive toxicity	oral	rat	Regulatory source
50	mg/kg bw/day	reproductive toxicity	oral	rat	Regulatory source
50	mg/kg bw / day	reproductive toxicity	oral	rat	Regulatory source
50	mg/kg bw/day	reproductive toxicity	dermal	rat	Regulatory source
=50	mg/kg bw/d	reproductive toxicity	oral	rat	Regulatory source
250	mg/kg bw/day	reproductive toxicity	oral	rat	Regulatory source
1000	mg/kg bw/day	reproductive toxicity	oral	rat	Regulatory source

Showing 31 of 31 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1631/21	23 July 2021	safe	0.5%	none noted

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

0.5%

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

E104 — ADI: 0.5 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for C.I. Acid Yellow 3 disodium salt?

C.I. Acid Yellow 3 disodium salt has 31 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.

What regulatory lists include C.I. Acid Yellow 3 disodium salt?

C.I. Acid Yellow 3 disodium salt appears on 13 regulatory/inventory lists including Arts and crafts/Office supplies - body paint - tattoo ink; Europe, Europe; Personal care - hair coloring, IFRA Transparency, and 10 more. Source: EPA CPDat.

Is C.I. Acid Yellow 3 disodium salt used in cosmetics?

Yes, C.I. Acid Yellow 3 disodium salt is also indexed as a cosmetic ingredient under the name D&C Yellow No. 10 (Quinoline Yellow). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for C.I. Acid Yellow 3 disodium salt come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is C.I. Acid Yellow 3 disodium salt used outside industrial chemicals?

C.I. Acid Yellow 3 disodium salt also appears in cosmetics, food safety, cannabis databases.