NOAEL Data Cosmetic Ingredient

(5beta,6alpha,7beta)-7,11,12-Trihydroxy-6,20-epoxyabieta-8(14),9(11),12-trien-20-one

CAS 80225-53-2

(5beta,6alpha,7beta)-7,11,12-Trihydroxy-6,20-epoxyabieta-8(14),9(11),12-trien-20-one (CAS 80225-53-2) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB.

View cosmetic safety profile for Rosmanol →

SOURCE noael studies public
NOAEL studies
4
SOURCE chemical inventory jurisdictions
Regulatory lists
0
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 6 fields
Name
(5beta,6alpha,7beta)-7,11,12-Trihydroxy-6,20-epoxyabieta-8(14),9(11),12-trien-20-one
CAS Number
80225-53-2
DTXSID
DTXSID80553423
Molecular Formula
C20H26O5
InChI Key
LCAZOMIGFDQMNC-FORWCCJISA-N
Monoisotopic Mass
346.178024

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 4 of 4 studies
ValueUnitEndpointRouteSpeciesSource
F25TV383OCUNIIFDA UNII substance identifier--openFDA substances
F25TV383OCUNIIFDA UNII substance identifier--openFDA substances
F25TV383OCUNIIFDA UNII substance identifier--openFDA substances
F25TV383OCUNIIFDA UNII substance identifier--openFDA substances

Showing 4 of 4 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
0.07-0.13% in rosemary CO2 extracts; no limits for rosemary extracts
Category
botanical extract
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ROSMANOL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for (5beta,6alpha,7beta)-7,11,12-Trihydroxy-6,20-epoxyabieta-8(14),9(11),12-trien-20-one?

(5beta,6alpha,7beta)-7,11,12-Trihydroxy-6,20-epoxyabieta-8(14),9(11),12-trien-20-one has 4 NOAEL studies in the database. The lowest reported value is F25TV383OC UNII. Source: openFDA substances.

Is (5beta,6alpha,7beta)-7,11,12-Trihydroxy-6,20-epoxyabieta-8(14),9(11),12-trien-20-one used in cosmetics?

Yes, (5beta,6alpha,7beta)-7,11,12-Trihydroxy-6,20-epoxyabieta-8(14),9(11),12-trien-20-one is also indexed as a cosmetic ingredient under the name Rosmanol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for (5beta,6alpha,7beta)-7,11,12-Trihydroxy-6,20-epoxyabieta-8(14),9(11),12-trien-20-one come from?

Safety data is sourced from EPA ToxValDB, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is (5beta,6alpha,7beta)-7,11,12-Trihydroxy-6,20-epoxyabieta-8(14),9(11),12-trien-20-one used outside industrial chemicals?

(5beta,6alpha,7beta)-7,11,12-Trihydroxy-6,20-epoxyabieta-8(14),9(11),12-trien-20-one also appears in cosmetics, pharmaceutical databases.