Also known as: Benzene, 1-(1,1-dimethylethyl)-3,5-dimethyl-2,4,6-trinitro-, 4-05-00-01132, Benzene, 1-tert-butyl-3,5-dimethyl-2,4,6-trinitro-, BRN 2015910, 5-tert-Butyl-2,4,6-trinitroxylene (+10 more)
CAS 81-15-2
Musk Xylene (CAS 81-15-2) is a chemical substance with GHS signal word Danger; key hazard signal: H201; H351; H400; H410. Key regulatory status: SVHC Candidate List, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA SVHC.
Musk Xylene is classified GHS Danger (H201, H351, H400, H410) in the chemicals database but is restricted in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1995 | 65 |
Candidate List status and reason under the ECHA REACH SVHC program.
| Substance | Reason | Included |
|---|---|---|
| 5-tert-butyl-2,4,6-trinitro-m-xylene (Musk xylene) | vPvB (Article 57e) | 28-Oct-2008 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Expl. 1.1; Carc. 2; Aquatic Acute 1; Aquatic Chronic 1 | H201; H351; H400; H410 | GHS01; GHS08; GHS09 | Danger |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| Europe | European Chemicals Agency | European Chemicals Agency (ECHA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =10 | mg/kg/d | - | - | mouse | UnifiedCodex:SCCNFP:beta.noael_studies |
| =10 | mg/kg/d | - | - | mouse | UnifiedCodex:SCCNFP:beta.noael_studies |
| 1ZAO16GU5K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1ZAO16GU5K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1ZAO16GU5K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1ZAO16GU5K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3240 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >10000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =10 | mg/kg/d | NOAEL | - | - | SCCNFP_vision_codex |
| =10 | mg/kg/d | NOAEL | - | - | SCCNFP_vision_codex |
| =10 | mg/kg/d | NOAEL | - | - | SCCNFP_vision_codex |
| =10 | mg/kg/d | NOAEL | - | - | SCCNFP_vision_codex |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 10 | mg/kg/d | carcinogenicity | - | mouse | UnifiedCodex:SCCNFP:beta.noael_studies |
| 10 | mg/kg/d | reproductive toxicity | - | - | UnifiedCodex:SCCNFP:beta.noael_studies |
Showing 18 of 18 studies
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Musk Xylene (CAS 81-15-2) is classified under EU CLP Annex VI as Expl. 1.1; Carc. 2; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H201; H351; H400; H410. Source: EU CLP Annex VI (ECHA).
Musk Xylene has 18 NOAEL studies in the database. The lowest reported value is 10 mg/kg/d in mouse. Source: UnifiedCodex:SCCNFP:beta.noael_studies.
Musk Xylene appears on 2 regulatory/inventory lists including Europe; Personal care; restricted, Europe. Source: EPA CPDat.
Musk Xylene is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1995). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, Musk Xylene is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: vPvB (Article 57e). Source: ECHA SVHC Candidate List.
Yes, Musk Xylene is also indexed as a cosmetic ingredient under the name Musk Xylene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA SVHC Candidate List, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Musk Xylene is classified GHS Danger (H201, H351, H400, H410) in the chemicals database but is restricted in EU cosmetics.
Musk Xylene also appears in cosmetics, pharmaceutical databases.