NOAEL Data Cosmetic Ingredient

Flavianic acid sodium salt

Also known as: 2-Naphthalenesulfonic acid, 8-hydroxy-5,7-dinitro-, sodium salt (1:2), 2-Naphthalenesulfonic acid, 5,7-dinitro-8-hydroxy-, disodium salt, C.I. Acid Yellow 1, disodium 5,7-dinitro-8-oxidonaphthalene-2-sulphonate, 1307 Yellow (+15 more)

CAS 846-70-8

Flavianic acid sodium salt (CAS 846-70-8) is a chemical substance. Key regulatory status: 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.

View cosmetic safety profile for CI 10316 (Ext. D&C Yellow No. 7) →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

Flavianic acid sodium salt

CAS Number

846-70-8

Molecular Formula

C10H6N2O8S.2Na

InChI Key

CTIQLGJVGNGFEW-UHFFFAOYSA-L

Monoisotopic Mass

359.964025

Synonyms

2-Naphthalenesulfonic acid, 8-hydroxy-5,7-dinitro-, sodium salt (1:2)2-Naphthalenesulfonic acid, 5,7-dinitro-8-hydroxy-, disodium saltC.I. Acid Yellow 1disodium 5,7-dinitro-8-oxidonaphthalene-2-sulphonate1307 Yellow1422 YellowA.F. Yellow No. 1Acid Leather Yellow NYSAmacid Yellow SCalcocid Yellow SDolkwal Naphthol Yellow SEdicol Supra Yellow Y

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 5 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care; restricted	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 21 of 21 studies

Value	Unit	Endpoint	Route	Species	Source
08F8S9O3I5	UNII	FDA UNII substance identifier	-	-	openFDA substances
concept	identifier	FDA UNII substance identifier	-	-	openFDA substances
30	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
=0	mg/kg bw/day	NOAEL	-	guinea pig	SCCNFP Opinion
=0.0009	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
=0.0011	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
=30	mg/kg bw/day	NOAEL	-	-	SCCS Opinion
=30	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
=30	mg/kg bw/day	NOAEL	dermal	-	SCCNFP Opinion
=50	mg/kg bw/day	NOAEL	-	human	SCCS Opinion
=50	mg/kg bw/day	NOAEL	-	pig	SCCNFP Opinion
=0.0009	mg/kg bw	dermal absorption	oral	rat	Regulatory source
=0.0011	mg/kg bw	dermal absorption	oral	rat	Regulatory source
=30	mg/kg bw	dermal absorption	oral	rat	Regulatory source
0	mg/kg bw/day	developmental toxicity	-	guinea pig	Regulatory source
30	mg/kg bw/day	developmental toxicity	-	human	Regulatory source
50	mg/kg bw/day	developmental toxicity	-	pig	Regulatory source
50	mg/kg bw/day	developmental toxicity	-	guinea pig	Regulatory source
50	mg/kg bw/day	developmental toxicity	-	human	Regulatory source
30	mg/kg bw/day	genotoxicity	-	-	Regulatory source
30	mg/kg bw/day	repeated dose toxicity	dermal	-	Regulatory source

Showing 21 of 21 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/1179/08	16 December 2008	not safe	-	low MoS; sensitisation; genotoxicity concerns
SCCP/1160/08	2008-12-16	The SCCP is of the opinion that, apart from the risks associated with the use of a sensitiser, the use of Acid Yellow 1 as an ingredient in oxidative hair dye formulations at a maximum on-head concentration of 1.0% and in non-oxidative hair dye formulations at a maximum on-head concentration of 0.2% does not pose a risk to the health of the consumer.	1.0% on-head (oxidative); 0.2% on-head (non-oxidative)	Considered a potent skin sensitiser. The stability of Acid Yellow 1 in oxidative hair dye formulations has not been demonstrated.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Permitted in all cosmetics except those applied in the vicinity of the eyes and lip products; no maximum concentration specified

Frequently Asked Questions

What is the NOAEL for Flavianic acid sodium salt?

Flavianic acid sodium salt has 21 NOAEL studies in the database. The lowest reported value is 08F8S9O3I5 UNII. Source: openFDA substances.

What regulatory lists include Flavianic acid sodium salt?

Flavianic acid sodium salt appears on 3 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Europe; Personal care - hair coloring, Europe; Personal care; restricted. Source: EPA CPDat.

Is Flavianic acid sodium salt used in cosmetics?

Yes, Flavianic acid sodium salt is also indexed as a cosmetic ingredient under the name CI 10316 (Ext. D&C Yellow No. 7). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Flavianic acid sodium salt come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is Flavianic acid sodium salt used outside industrial chemicals?

Flavianic acid sodium salt also appears in cosmetics databases.