What is the NOAEL for Milk thistle extract?
Milk thistle extract has 5 NOAEL studies in the database. The lowest reported value is concept identifier. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Milk thistle extract
Also known as: Silybum marianum extracts, Flavopherol, EINECS 283-298-7, Lady's thistle (Silybum marianum L. Gaertner), Milk thistle extracts
CAS 84604-20-6
Milk thistle extract (CAS 84604-20-6) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Nannochloropsis Oculata Extract →
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
8 fields
Name
Milk thistle extract
CAS Number
84604-20-6
DTXSID
DTXSID8031657
Synonyms
Silybum marianum extractsFlavopherolEINECS 283-298-7Lady's thistle (Silybum marianum L. Gaertner)Milk thistle extracts
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
Softener and conditionerHumectant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| concept | identifier | FDA UNII substance identifier | - | - | openFDA substances |
| 50000 | ppm | Top dose | Dosed feed | Rat | NTP_ICE_cancer |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Silybum marianum, ext. | 283-298-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ChEMBL Phase
Not listed
Adverse Events
582
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Milk thistle extract?
Milk thistle extract appears on 1 regulatory/inventory list including Canada; Personal care; Substances in PCP - Canada (4/2014). Source: EPA CPDat.
Is Milk thistle extract used in cosmetics?
Yes, Milk thistle extract is also indexed as a cosmetic ingredient under the name Nannochloropsis Oculata Extract. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Milk thistle extract come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Milk thistle extract used outside industrial chemicals?
Milk thistle extract also appears in cosmetics, pharmaceutical, food safety databases.