NOAEL Data REACH Registered Cosmetic Ingredient

Lawsonia inermis, extract

Also known as: Henna

CAS 84988-66-9

Lawsonia inermis, extract (CAS 84988-66-9) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Lawsonia Inermis Leaf Extract →

SOURCE noael studies public
NOAEL studies
80
SOURCE chemical inventory jurisdictions
Regulatory lists
5
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 4 fields
Name
Lawsonia inermis, extract
CAS Number
84988-66-9
DTXSID
DTXSID80904971
Synonyms
Henna

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 16 records
BiocideAntioxidantDeodorizerSoftener and conditionerDyeFiller

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records
ListKeywordSource
Personal careFDAUnited States Food and Drug Administration (FDA)
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 80 studies
ValueUnitEndpointRouteSpeciesSource
200mg/kg/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
200mg/kg/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=0.00833mg/kg bw/dNOAELdermal-SCCS_vision_codex
=0.00833mg/kg bw/dNOAELdermal-SCCS_vision_codex
=0.00833mg/kg bw/dNOAELdermal-SCCS_vision_codex
=0.00833mg/kg bw/dNOAELdermal-SCCS_vision_codex
=2mg/kg bw/dNOAELdermal-SCCS_vision_codex
=2mg/kg bw/dNOAELdermal-SCCS_vision_codex
=2mg/kg bw/dNOAELdermal-SCCS_vision_codex
=2mg/kg bw/dNOAELdermal-SCCS_vision_codex
=7mg/kg bwNOAELoralratSCCS_vision_codex
=7mg/kg bwNOAELoralratSCCS_vision_codex
=7mg/kg bwNOAELoralratSCCS_vision_codex
=7mg/kg bwNOAELoralratSCCS_vision_codex
=20%NOAELdermalrabbitSCCNFP_vision_codex
=20%NOAELdermalrabbitSCCNFP_vision_codex
=20%NOAELdermalrabbitSCCNFP_vision_codex
=20%NOAELdermalrabbitSCCNFP_vision_codex
=40mg/kg bwNOAEL--SCCS_vision_codex
=40mg/kg bw/dayNOAELoralratSCCS_vision_codex
=40mg/kg bwNOAEL--SCCNFP_vision_codex
=40mg/kg/dayNOAELoralratSCCNFP_vision_codex
=40mg/kg bwNOAEL--SCCS_vision_codex
=40mg/kg bwNOAEL--SCCS_vision_codex
=40mg/kg bw/dayNOAELoralratSCCS_vision_codex
=40mg/kg bw/dayNOAELoralratSCCS_vision_codex
=40mg/kg bwNOAEL--SCCNFP_vision_codex
=40mg/kg/dayNOAELoralratSCCNFP_vision_codex
=40mg/kg bwNOAEL--SCCNFP_vision_codex
=40mg/kg/dayNOAELoralratSCCNFP_vision_codex
=40mg/kg bwNOAEL--SCCS_vision_codex
=40mg/kg bw/dayNOAELoralratSCCS_vision_codex
=40mg/kg bwNOAEL--SCCNFP_vision_codex
=40mg/kg/dayNOAELoralratSCCNFP_vision_codex
=200mg/kg/dayNOAEL-ratSCCS_vision_codex
=200mg/kg/dayNOAEL-ratSCCS_vision_codex
=200mg/kg bw/dayNOAELoralratSCCS_vision_codex
=200mg/kg/dayNOAEL-ratSCCNFP_vision_codex
=200mg/kg/dayNOAEL-ratSCCS_vision_codex
=200mg/kg/dayNOAEL-ratSCCS_vision_codex
=200mg/kg/dayNOAEL-ratSCCS_vision_codex
=200mg/kg bw/dayNOAELoralratSCCS_vision_codex
=200mg/kg/dayNOAEL-ratSCCS_vision_codex
=200mg/kg bw/dayNOAELoralratSCCS_vision_codex
=200mg/kg/dayNOAEL-ratSCCNFP_vision_codex
=200mg/kg/dayNOAEL-ratSCCNFP_vision_codex
=200mg/kg/dayNOAEL-ratSCCS_vision_codex
=200mg/kg/dayNOAEL-ratSCCS_vision_codex
=200mg/kg bw/dayNOAELoralratSCCS_vision_codex
=200mg/kg/dayNOAEL-ratSCCNFP_vision_codex

Showing 50 of 80 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredLawsonia inermis, ext.284-854-1ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 2 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1511/1319 September 2013safe20% powder (max 1.4% lawsone)weak sensitisation; genotoxicity of lawsone
SCCP/0943/0513 December 2005safeN/A (per national tradition)sensitisation; presence of lawsone; further data on genotoxicity of lawsone recommended

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Botanical Extract
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for Lawsonia inermis, extract?

Lawsonia inermis, extract has 80 NOAEL studies in the database. The lowest reported value is 0.00833 mg/kg bw/d via dermal. Source: SCCS_vision_codex.

What regulatory lists include Lawsonia inermis, extract?

Lawsonia inermis, extract appears on 2 regulatory/inventory lists including Personal care, Europe; Personal care - hair coloring. Source: EPA CPDat.

Is Lawsonia inermis, extract used in cosmetics?

Yes, Lawsonia inermis, extract is also indexed as a cosmetic ingredient under the name Lawsonia Inermis Leaf Extract. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Lawsonia inermis, extract come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is Lawsonia inermis, extract used outside industrial chemicals?

Lawsonia inermis, extract also appears in cosmetics databases.